Early platelet transfusion improves platelet activity and may improve outcomes after intracerebral hemorrhage

Andrew M. Naidech, Storm M. Liebling, Neil F. Rosenberg, Paul F. Lindholm, Richard A. Bernstein, H. Hunt Batjer, Mark J. Alberts, Hau C. Kwaan

Research output: Contribution to journalArticle

75 Citations (Scopus)

Abstract

Background In patients with acute intracerebral hemorrhage (ICH), reduced platelet activity on admission predicts hemorrhage growth and poor outcomes. We tested the hypotheses that platelet transfusion improves measured platelet activity. Further, we hypothesized that earlier treatment in patients at high risk for hemorrhage growth and poor outcome would reduce follow-up hemorrhage size and poor clinical outcomes. Methods We prospectively identified consecutive patients with ICH who had reduced platelet activity on admission and received a platelet transfusion. We defined high-risk patients as per a previous publication, reduced platelet activity, or known anti-platelet therapy (APT) and the diagnostic CT within 12 h of symptom onset. Platelet activity was measured with the VerifyNow-ASA (Accumetrics, CA), ICH volumes on CT with computerized quantitative techniques, and functional outcomes with the modified Rankin Scale (mRS) at 3 months. Results Forty-five patients received a platelet transfusion with an increase in platelet activity from 472 ± 50 (consistent with an aspirin effect) to 561 ± 92 aspirin reaction units (consistent with no aspirin effect, P < 0.001). For high-risk patients, platelet transfusion within 12 h of symptom onset, as opposed to > 12 h, was associated with smaller follow-up hemorrhage size (8.4 [3-17.4] vs. 13.8 [12.3-62.5] ml, P = 0.04) and increased odds of independence (mRS < 4) at 3 months (11 of 20 vs. 0 of 7, P = 0.01). There were similar results for patients with known APT. Conclusions In patients at high risk for hemorrhage growth and poor outcome, early platelet transfusion improved platelet activity assay results and was associated with smaller final hemorrhage size and more independence at 3 months.

Original languageEnglish (US)
Pages (from-to)82-87
Number of pages6
JournalNeurocritical Care
Volume16
Issue number1
DOIs
StatePublished - Feb 2012

Fingerprint

Platelet Transfusion
Cerebral Hemorrhage
Blood Platelets
Hemorrhage
Aspirin
Growth
Cone-Beam Computed Tomography
Therapeutics

Keywords

  • Intracerebral hemorrhage
  • Outcomes
  • Platelets

ASJC Scopus subject areas

  • Clinical Neurology
  • Critical Care and Intensive Care Medicine

Cite this

Naidech, A. M., Liebling, S. M., Rosenberg, N. F., Lindholm, P. F., Bernstein, R. A., Batjer, H. H., ... Kwaan, H. C. (2012). Early platelet transfusion improves platelet activity and may improve outcomes after intracerebral hemorrhage. Neurocritical Care, 16(1), 82-87. https://doi.org/10.1007/s12028-011-9619-3

Early platelet transfusion improves platelet activity and may improve outcomes after intracerebral hemorrhage. / Naidech, Andrew M.; Liebling, Storm M.; Rosenberg, Neil F.; Lindholm, Paul F.; Bernstein, Richard A.; Batjer, H. Hunt; Alberts, Mark J.; Kwaan, Hau C.

In: Neurocritical Care, Vol. 16, No. 1, 02.2012, p. 82-87.

Research output: Contribution to journalArticle

Naidech, Andrew M. ; Liebling, Storm M. ; Rosenberg, Neil F. ; Lindholm, Paul F. ; Bernstein, Richard A. ; Batjer, H. Hunt ; Alberts, Mark J. ; Kwaan, Hau C. / Early platelet transfusion improves platelet activity and may improve outcomes after intracerebral hemorrhage. In: Neurocritical Care. 2012 ; Vol. 16, No. 1. pp. 82-87.
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AB - Background In patients with acute intracerebral hemorrhage (ICH), reduced platelet activity on admission predicts hemorrhage growth and poor outcomes. We tested the hypotheses that platelet transfusion improves measured platelet activity. Further, we hypothesized that earlier treatment in patients at high risk for hemorrhage growth and poor outcome would reduce follow-up hemorrhage size and poor clinical outcomes. Methods We prospectively identified consecutive patients with ICH who had reduced platelet activity on admission and received a platelet transfusion. We defined high-risk patients as per a previous publication, reduced platelet activity, or known anti-platelet therapy (APT) and the diagnostic CT within 12 h of symptom onset. Platelet activity was measured with the VerifyNow-ASA (Accumetrics, CA), ICH volumes on CT with computerized quantitative techniques, and functional outcomes with the modified Rankin Scale (mRS) at 3 months. Results Forty-five patients received a platelet transfusion with an increase in platelet activity from 472 ± 50 (consistent with an aspirin effect) to 561 ± 92 aspirin reaction units (consistent with no aspirin effect, P < 0.001). For high-risk patients, platelet transfusion within 12 h of symptom onset, as opposed to > 12 h, was associated with smaller follow-up hemorrhage size (8.4 [3-17.4] vs. 13.8 [12.3-62.5] ml, P = 0.04) and increased odds of independence (mRS < 4) at 3 months (11 of 20 vs. 0 of 7, P = 0.01). There were similar results for patients with known APT. Conclusions In patients at high risk for hemorrhage growth and poor outcome, early platelet transfusion improved platelet activity assay results and was associated with smaller final hemorrhage size and more independence at 3 months.

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