Early prediction of acute antidepressant treatment response and remission in pediatric major depressive disorder

Rongrong Tao, Graham Emslie, Taryn Mayes, Paul Nakonezny, Betsy Kennard, Carroll Hughes

Research output: Contribution to journalArticle

36 Citations (Scopus)

Abstract

Objective: Less than half of youths achieve remission (minimal to no symptoms) after acute antidepressant treatment. Early identification of who will or will not respond to treatment and achieve remission may help clinicians formulate treatment decisions and shorten the time spent on ineffective treatments. In a prospective open-label fluoxetine study, we investigate indicators of acute treatment response and remission. Method: One hundred sixty-eight children and adolescents, ages 7 to 18 years, with primary diagnoses of major depressive disorder received 12 weeks of fluoxetine treatment. The youths were evaluated using the Kiddie Schedule for Affective Disorders and Schizophrenia. The outcome measure included the Children's Depression Rating Scale-Revised. Results: Positive first-degree family history of depression was the only baseline demographic and clinical characteristic that predicted a favorable treatment response (p = .01). The rate of symptom improvement, however, is a good indicator of acute treatment response. A significant symptom reduction (approximately 50%) by week 4 is needed to achieve remission at the end of acute treatment. Conclusions: This study demonstrated that the rate of symptom improvement during early weeks of acute fluoxetine treatment is a good indicator of remission. Treatment approach may be reevaluated and modified as early as week 4 during acute treatment.

Original languageEnglish (US)
Pages (from-to)71-78
Number of pages8
JournalJournal of the American Academy of Child and Adolescent Psychiatry
Volume48
Issue number1
DOIs
StatePublished - Jan 2009

Fingerprint

Major Depressive Disorder
Antidepressive Agents
Pediatrics
Fluoxetine
Therapeutics
Depression
Mood Disorders
Schizophrenia
Appointments and Schedules
Demography
Outcome Assessment (Health Care)

Keywords

  • Acute treatment
  • Fluoxetine
  • Pediatric depression

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Developmental and Educational Psychology

Cite this

@article{54c4ade57a5e486494e2b1df9368bbaa,
title = "Early prediction of acute antidepressant treatment response and remission in pediatric major depressive disorder",
abstract = "Objective: Less than half of youths achieve remission (minimal to no symptoms) after acute antidepressant treatment. Early identification of who will or will not respond to treatment and achieve remission may help clinicians formulate treatment decisions and shorten the time spent on ineffective treatments. In a prospective open-label fluoxetine study, we investigate indicators of acute treatment response and remission. Method: One hundred sixty-eight children and adolescents, ages 7 to 18 years, with primary diagnoses of major depressive disorder received 12 weeks of fluoxetine treatment. The youths were evaluated using the Kiddie Schedule for Affective Disorders and Schizophrenia. The outcome measure included the Children's Depression Rating Scale-Revised. Results: Positive first-degree family history of depression was the only baseline demographic and clinical characteristic that predicted a favorable treatment response (p = .01). The rate of symptom improvement, however, is a good indicator of acute treatment response. A significant symptom reduction (approximately 50{\%}) by week 4 is needed to achieve remission at the end of acute treatment. Conclusions: This study demonstrated that the rate of symptom improvement during early weeks of acute fluoxetine treatment is a good indicator of remission. Treatment approach may be reevaluated and modified as early as week 4 during acute treatment.",
keywords = "Acute treatment, Fluoxetine, Pediatric depression",
author = "Rongrong Tao and Graham Emslie and Taryn Mayes and Paul Nakonezny and Betsy Kennard and Carroll Hughes",
year = "2009",
month = "1",
doi = "10.1097/CHI.0b013e318190043e",
language = "English (US)",
volume = "48",
pages = "71--78",
journal = "Journal of the American Academy of Child and Adolescent Psychiatry",
issn = "0890-8567",
publisher = "Elsevier Limited",
number = "1",

}

TY - JOUR

T1 - Early prediction of acute antidepressant treatment response and remission in pediatric major depressive disorder

AU - Tao, Rongrong

AU - Emslie, Graham

AU - Mayes, Taryn

AU - Nakonezny, Paul

AU - Kennard, Betsy

AU - Hughes, Carroll

PY - 2009/1

Y1 - 2009/1

N2 - Objective: Less than half of youths achieve remission (minimal to no symptoms) after acute antidepressant treatment. Early identification of who will or will not respond to treatment and achieve remission may help clinicians formulate treatment decisions and shorten the time spent on ineffective treatments. In a prospective open-label fluoxetine study, we investigate indicators of acute treatment response and remission. Method: One hundred sixty-eight children and adolescents, ages 7 to 18 years, with primary diagnoses of major depressive disorder received 12 weeks of fluoxetine treatment. The youths were evaluated using the Kiddie Schedule for Affective Disorders and Schizophrenia. The outcome measure included the Children's Depression Rating Scale-Revised. Results: Positive first-degree family history of depression was the only baseline demographic and clinical characteristic that predicted a favorable treatment response (p = .01). The rate of symptom improvement, however, is a good indicator of acute treatment response. A significant symptom reduction (approximately 50%) by week 4 is needed to achieve remission at the end of acute treatment. Conclusions: This study demonstrated that the rate of symptom improvement during early weeks of acute fluoxetine treatment is a good indicator of remission. Treatment approach may be reevaluated and modified as early as week 4 during acute treatment.

AB - Objective: Less than half of youths achieve remission (minimal to no symptoms) after acute antidepressant treatment. Early identification of who will or will not respond to treatment and achieve remission may help clinicians formulate treatment decisions and shorten the time spent on ineffective treatments. In a prospective open-label fluoxetine study, we investigate indicators of acute treatment response and remission. Method: One hundred sixty-eight children and adolescents, ages 7 to 18 years, with primary diagnoses of major depressive disorder received 12 weeks of fluoxetine treatment. The youths were evaluated using the Kiddie Schedule for Affective Disorders and Schizophrenia. The outcome measure included the Children's Depression Rating Scale-Revised. Results: Positive first-degree family history of depression was the only baseline demographic and clinical characteristic that predicted a favorable treatment response (p = .01). The rate of symptom improvement, however, is a good indicator of acute treatment response. A significant symptom reduction (approximately 50%) by week 4 is needed to achieve remission at the end of acute treatment. Conclusions: This study demonstrated that the rate of symptom improvement during early weeks of acute fluoxetine treatment is a good indicator of remission. Treatment approach may be reevaluated and modified as early as week 4 during acute treatment.

KW - Acute treatment

KW - Fluoxetine

KW - Pediatric depression

UR - http://www.scopus.com/inward/record.url?scp=58249131466&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=58249131466&partnerID=8YFLogxK

U2 - 10.1097/CHI.0b013e318190043e

DO - 10.1097/CHI.0b013e318190043e

M3 - Article

C2 - 19057412

AN - SCOPUS:58249131466

VL - 48

SP - 71

EP - 78

JO - Journal of the American Academy of Child and Adolescent Psychiatry

JF - Journal of the American Academy of Child and Adolescent Psychiatry

SN - 0890-8567

IS - 1

ER -