Early predictors of continuous positive airway pressure failure in preterm neonates

Venkatakrishna Kakkilaya, Sheron Wagner, Kate Louise M Mangona, L. Steven Brown, Ihab Jubran, Henry He, Rashmin C Savani, Vishal S Kapadia

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Objective: To develop a prediction model to identify infants admitted on continuous positive airway pressure (CPAP) requiring intubation within seventy-two hours of life (HOL). Study design: Infants born ≤29 weeks’ gestational age between 2013 and April 2018 were randomly assigned to either a modeling cohort (MC) or a validation cohort (VC) in a 2:1 ratio. Variables available within two HOL were compared between the CPAP failure group (CFG) and the CPAP success group (CSG). Results: Of the 189 infants in the MC, 50% failed CPAP. Compared to CSG, infants in the CFG had lower antenatal steroid exposure, birth weight, higher radiographic severe respiratory distress syndrome (RDS) and fraction of inspired oxygen (FiO 2 ). A forward stepwise logistic regression modeling in both MC and VC showed that FiO 2 >0.3 and radiographic severe RDS predicted CPAP failure. Conclusion: FiO 2 >0.3 within two HOL and radiographic severe RDS predicts CPAP failure in preterm infants.

Original languageEnglish (US)
JournalJournal of Perinatology
DOIs
StatePublished - Jan 1 2019

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Continuous Positive Airway Pressure
Newborn Infant
Intubation
Birth Weight
Premature Infants
Gestational Age
Logistic Models
Steroids
Oxygen

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Obstetrics and Gynecology

Cite this

Early predictors of continuous positive airway pressure failure in preterm neonates. / Kakkilaya, Venkatakrishna; Wagner, Sheron; Mangona, Kate Louise M; Steven Brown, L.; Jubran, Ihab; He, Henry; Savani, Rashmin C; Kapadia, Vishal S.

In: Journal of Perinatology, 01.01.2019.

Research output: Contribution to journalArticle

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AU - Wagner, Sheron

AU - Mangona, Kate Louise M

AU - Steven Brown, L.

AU - Jubran, Ihab

AU - He, Henry

AU - Savani, Rashmin C

AU - Kapadia, Vishal S

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