Eating oneself and uninvited guests: Autophagy-related pathways in cellular defense

Research output: Contribution to journalReview article

593 Scopus citations


The eukaryotic cell uses an evolutionarily conserved lysosomal pathway of self-digestion (autophagy) for survival when extracellular nutrients are limited. In this issue of Cell, new evidence indicates that autophagy is used to for survival when intracellular nutrients are limited by growth factor deprivation (Lum et al., 2005). Other recent studies indicate that the autophagy machinery is also used to degrade foreign microbial invaders (xenophagy).

Original languageEnglish (US)
Pages (from-to)159-162
Number of pages4
Issue number2
StatePublished - Jan 28 2005


ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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