TY - JOUR
T1 - Eating the enemy within
T2 - Autophagy in infectious diseases
AU - Orvedahl, A.
AU - Levine, B.
N1 - Funding Information:
Acknowledgements. We apologize to authors whose work could not be included due to space restrictions. We thank Cindy Jozefiak for administrative support, and Angela Diehl for expert medical illustration. The work in the authors’ laboratory was supported by NIH Grants R01 A10151367 (BL) and T32 A1007520 (AO), and an Ellison Medical Foundation Senior Scholars Award in Infectious Diseases (BL).
PY - 2009
Y1 - 2009
N2 - Autophagy is emerging as a central component of antimicrobial host defense against diverse viral, bacterial, and parasitic infections. In addition to pathogen degradation, autophagy has other functions during infection such as innate and adaptive immune activation. As an important host defense pathway, microbes have also evolved mechanisms to evade, subvert, or exploit autophagy. Additionally, some fungal pathogens harness autophagy within their own cells to promote pathogenesis. This review will highlight our current understanding of autophagy in infection, focusing on the most recent advances in the field, and will discuss the potential implications of these studies in the design of anti-infective therapeutics.
AB - Autophagy is emerging as a central component of antimicrobial host defense against diverse viral, bacterial, and parasitic infections. In addition to pathogen degradation, autophagy has other functions during infection such as innate and adaptive immune activation. As an important host defense pathway, microbes have also evolved mechanisms to evade, subvert, or exploit autophagy. Additionally, some fungal pathogens harness autophagy within their own cells to promote pathogenesis. This review will highlight our current understanding of autophagy in infection, focusing on the most recent advances in the field, and will discuss the potential implications of these studies in the design of anti-infective therapeutics.
UR - http://www.scopus.com/inward/record.url?scp=57649166494&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=57649166494&partnerID=8YFLogxK
U2 - 10.1038/cdd.2008.130
DO - 10.1038/cdd.2008.130
M3 - Review article
C2 - 18772897
AN - SCOPUS:57649166494
SN - 1350-9047
VL - 16
SP - 57
EP - 69
JO - Cell Death and Differentiation
JF - Cell Death and Differentiation
IS - 1
ER -