Echocardiographic predictors of symptomatic patent ductus arteriosus in extremely-low-birth-weight preterm neonates

F. G. Ramos, C. R. Rosenfeld, L. Roy, J. Koch, C. Ramaciotti

Research output: Contribution to journalArticle

35 Scopus citations


Objective:Identify echocardiographic parameters at ≤ 4 day postnatal that predict the subsequent need for closure of a clinically significant patent ductus arteriosus (sPDA) in extremely-low-birth-weight neonates (ELBW).Study Design: Serial echocardiograms obtained in 115 ELBW at ≤ 10 day postnatal were examined to estimate PDA size using the PDA:left pulmonary artery (LPA) diameter ratio: ≥ 1 indicated a large PDA, < 1 but ≥ 0.5 moderate, and < 0.5 small. Sensitivity, specificity, and positive predictive values (PPV) were determined for ELBW < 27 weeks and ≥ 27 weeks gestational age.Result:Neonates with moderate to large PDA at ≤ 4 day had 15-times greater likelihood of requiring treatment for sPDA than those with a small PDA (95% confidence interval (CI): 5.6-41). Sensitivity, specificity and PPV of the PDA:LPA at < 27 weeks was 80, 86 and 92%, respectively.Conclusion:A moderate to large PDA determined from the PDA:LPA ratio at ≤4 day postnatal identifies neonates < 27 week gestation who subsequently require closure of a PDA.

Original languageEnglish (US)
Pages (from-to)535-539
Number of pages5
JournalJournal of Perinatology
Issue number8
Publication statusPublished - Aug 2010



  • clinically significant patent ductus arteriosus
  • ductus arteriosus
  • positive predictive value
  • pulmonary artery diameter
  • sensitivity

ASJC Scopus subject areas

  • Obstetrics and Gynecology
  • Pediatrics, Perinatology, and Child Health

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