Objective:Identify echocardiographic parameters at ≤ 4 day postnatal that predict the subsequent need for closure of a clinically significant patent ductus arteriosus (sPDA) in extremely-low-birth-weight neonates (ELBW).Study Design: Serial echocardiograms obtained in 115 ELBW at ≤ 10 day postnatal were examined to estimate PDA size using the PDA:left pulmonary artery (LPA) diameter ratio: ≥ 1 indicated a large PDA, < 1 but ≥ 0.5 moderate, and < 0.5 small. Sensitivity, specificity, and positive predictive values (PPV) were determined for ELBW < 27 weeks and ≥ 27 weeks gestational age.Result:Neonates with moderate to large PDA at ≤ 4 day had 15-times greater likelihood of requiring treatment for sPDA than those with a small PDA (95% confidence interval (CI): 5.6-41). Sensitivity, specificity and PPV of the PDA:LPA at < 27 weeks was 80, 86 and 92%, respectively.Conclusion:A moderate to large PDA determined from the PDA:LPA ratio at ≤4 day postnatal identifies neonates < 27 week gestation who subsequently require closure of a PDA.
- clinically significant patent ductus arteriosus
- ductus arteriosus
- positive predictive value
- pulmonary artery diameter
ASJC Scopus subject areas
- Obstetrics and Gynecology
- Pediatrics, Perinatology, and Child Health