ECOD: Identification of distant homology among multidomain and transmembrane domain proteins

R. Dustin Schaeffer, Lisa Kinch, Kirill E. Medvedev, Jimin Pei, Hua Cheng, Nick Grishin

Research output: Contribution to journalArticlepeer-review

8 Scopus citations


The manual classification of protein domains is approaching its 20th anniversary. ECOD is our mixed manual-automatic domain classification. Over time, the types of proteins which require manual curation has changed. Depositions with complex multidomain and multichain arrangements are commonplace. Transmembrane domains are regularly classified. Repeatedly, domains which are initially believed to be novel are found to have homologous links to existing classified domains. Here we present a brief summary of recent manual curation efforts in ECOD generally combined with specific case studies of transmembrane and multidomain proteins wherein manual curation was useful for discovering new homologous relationships. We present a new taxonomy for the classification of ABC transporter transmembrane domains. We examine alternate topologies of the leucine-specific (LS) domain of Leucine tRNA-synthetase. Finally, we elaborate on a distant homologous links between two helical dimerization domains.

Original languageEnglish (US)
Article number18
JournalBMC Molecular and Cell Biology
Issue number1
StatePublished - Jun 21 2019
Externally publishedYes

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology


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