Ectopic production and localization of β-human chorionic gonadotropin in lymphoepithelioma-like carcinoma of the cervix

A case report

Robert L. Coleman, Guy Lindberg, Carolyn Y. Muller, David S. Miller, Arif Hameed

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

A 32-year-old woman underwent a suction curettage for missed abortion. The initial serum human chorionic gonadotropin (β-hCG) level was 40 IU/ml. The histologic examination of the uterine curettage specimen showed scant strips of a poorly differentiated malignant neoplasm and no chorionic villi. The tumor showed strong immunoreactivity for cytokeratin (AE1/AE3) and β-hCG but no reactivity for human placental lactogen. The combination of histologic appearance, β-hCG immunoreactivity, and elevation of serum β-hCG raised a strong suspicion for epithelioid trophoblastic tumor (ETT). Postcurettage serial serum β-hCG levels remained in the range of 20 to 45 μg/ml. Computerized tomographic scan showed a 1.0-cm circumscribed mass in the upper endocervix. A radical hysterectomy and pelvic lymphadenectomy were performed. Gross examination of the hysterectomy specimen likewise showed a well- circumscribed mass in the upper endocervix. Histologic examination revealed an undifferentiated carcinoma accompanied by intense lymphoplasmacytic infiltrate. A final diagnosis of lymphoepithelioma-like carcinoma (LELC) was rendered. LELC with elevated serum β-hCG level and immunoreactivity to β- hCG should be distinguished from ETT in a small endocervical curettage sample.

Original languageEnglish (US)
Pages (from-to)179-182
Number of pages4
JournalInternational Journal of Gynecological Pathology
Volume19
Issue number2
StatePublished - Apr 2000

Fingerprint

Chorionic Gonadotropin
Cervix Uteri
Trophoblastic Neoplasms
Carcinoma
Curettage
Serum
Hysterectomy
Vacuum Curettage
Missed Abortion
Placental Lactogen
Chorionic Villi
Keratins
Lymph Node Excision
Neoplasms

Keywords

  • β-hCG
  • Lymphoepithelioma-like carcinoma
  • Uterine cervix

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Obstetrics and Gynecology

Cite this

Ectopic production and localization of β-human chorionic gonadotropin in lymphoepithelioma-like carcinoma of the cervix : A case report. / Coleman, Robert L.; Lindberg, Guy; Muller, Carolyn Y.; Miller, David S.; Hameed, Arif.

In: International Journal of Gynecological Pathology, Vol. 19, No. 2, 04.2000, p. 179-182.

Research output: Contribution to journalArticle

@article{cf0605bfc4844b36afb198b1d89911a3,
title = "Ectopic production and localization of β-human chorionic gonadotropin in lymphoepithelioma-like carcinoma of the cervix: A case report",
abstract = "A 32-year-old woman underwent a suction curettage for missed abortion. The initial serum human chorionic gonadotropin (β-hCG) level was 40 IU/ml. The histologic examination of the uterine curettage specimen showed scant strips of a poorly differentiated malignant neoplasm and no chorionic villi. The tumor showed strong immunoreactivity for cytokeratin (AE1/AE3) and β-hCG but no reactivity for human placental lactogen. The combination of histologic appearance, β-hCG immunoreactivity, and elevation of serum β-hCG raised a strong suspicion for epithelioid trophoblastic tumor (ETT). Postcurettage serial serum β-hCG levels remained in the range of 20 to 45 μg/ml. Computerized tomographic scan showed a 1.0-cm circumscribed mass in the upper endocervix. A radical hysterectomy and pelvic lymphadenectomy were performed. Gross examination of the hysterectomy specimen likewise showed a well- circumscribed mass in the upper endocervix. Histologic examination revealed an undifferentiated carcinoma accompanied by intense lymphoplasmacytic infiltrate. A final diagnosis of lymphoepithelioma-like carcinoma (LELC) was rendered. LELC with elevated serum β-hCG level and immunoreactivity to β- hCG should be distinguished from ETT in a small endocervical curettage sample.",
keywords = "β-hCG, Lymphoepithelioma-like carcinoma, Uterine cervix",
author = "Coleman, {Robert L.} and Guy Lindberg and Muller, {Carolyn Y.} and Miller, {David S.} and Arif Hameed",
year = "2000",
month = "4",
language = "English (US)",
volume = "19",
pages = "179--182",
journal = "International Journal of Gynecological Pathology",
issn = "0277-1691",
publisher = "Lippincott Williams and Wilkins",
number = "2",

}

TY - JOUR

T1 - Ectopic production and localization of β-human chorionic gonadotropin in lymphoepithelioma-like carcinoma of the cervix

T2 - A case report

AU - Coleman, Robert L.

AU - Lindberg, Guy

AU - Muller, Carolyn Y.

AU - Miller, David S.

AU - Hameed, Arif

PY - 2000/4

Y1 - 2000/4

N2 - A 32-year-old woman underwent a suction curettage for missed abortion. The initial serum human chorionic gonadotropin (β-hCG) level was 40 IU/ml. The histologic examination of the uterine curettage specimen showed scant strips of a poorly differentiated malignant neoplasm and no chorionic villi. The tumor showed strong immunoreactivity for cytokeratin (AE1/AE3) and β-hCG but no reactivity for human placental lactogen. The combination of histologic appearance, β-hCG immunoreactivity, and elevation of serum β-hCG raised a strong suspicion for epithelioid trophoblastic tumor (ETT). Postcurettage serial serum β-hCG levels remained in the range of 20 to 45 μg/ml. Computerized tomographic scan showed a 1.0-cm circumscribed mass in the upper endocervix. A radical hysterectomy and pelvic lymphadenectomy were performed. Gross examination of the hysterectomy specimen likewise showed a well- circumscribed mass in the upper endocervix. Histologic examination revealed an undifferentiated carcinoma accompanied by intense lymphoplasmacytic infiltrate. A final diagnosis of lymphoepithelioma-like carcinoma (LELC) was rendered. LELC with elevated serum β-hCG level and immunoreactivity to β- hCG should be distinguished from ETT in a small endocervical curettage sample.

AB - A 32-year-old woman underwent a suction curettage for missed abortion. The initial serum human chorionic gonadotropin (β-hCG) level was 40 IU/ml. The histologic examination of the uterine curettage specimen showed scant strips of a poorly differentiated malignant neoplasm and no chorionic villi. The tumor showed strong immunoreactivity for cytokeratin (AE1/AE3) and β-hCG but no reactivity for human placental lactogen. The combination of histologic appearance, β-hCG immunoreactivity, and elevation of serum β-hCG raised a strong suspicion for epithelioid trophoblastic tumor (ETT). Postcurettage serial serum β-hCG levels remained in the range of 20 to 45 μg/ml. Computerized tomographic scan showed a 1.0-cm circumscribed mass in the upper endocervix. A radical hysterectomy and pelvic lymphadenectomy were performed. Gross examination of the hysterectomy specimen likewise showed a well- circumscribed mass in the upper endocervix. Histologic examination revealed an undifferentiated carcinoma accompanied by intense lymphoplasmacytic infiltrate. A final diagnosis of lymphoepithelioma-like carcinoma (LELC) was rendered. LELC with elevated serum β-hCG level and immunoreactivity to β- hCG should be distinguished from ETT in a small endocervical curettage sample.

KW - β-hCG

KW - Lymphoepithelioma-like carcinoma

KW - Uterine cervix

UR - http://www.scopus.com/inward/record.url?scp=0034001265&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0034001265&partnerID=8YFLogxK

M3 - Article

VL - 19

SP - 179

EP - 182

JO - International Journal of Gynecological Pathology

JF - International Journal of Gynecological Pathology

SN - 0277-1691

IS - 2

ER -