Effect of β adrenergic blockade and inhibitors of angiotensin II and prostaglandins on renal autoregulation

R. J. Anderson, M. S. Taher, R. E. Cronin, K. M. McDonald, R. W. Schrier

Research output: Chapter in Book/Report/Conference proceedingChapter

28 Citations (Scopus)

Abstract

The role of the renin angiotensin system and prostaglandins in renal autoregulation was investigated in dog kidneys in situ. Renal autoregulation during decreases in renal arterial pressure (RAP) was examined in animals pretreated with a competitive antagonist of angiotensin II, [1 sarcosine, 8 glycine] angiotensin II, or one of two chemically dissimilar inhibitors of prostaglandin synthetase, indomethacin and meclofenamate. Because of recent evidence suggesting a role for an intrarenal beta receptor in regulating renin release, renal autoregulation was also examined in animals treated with the beta adrenergic blocking agent propranolol. In all groups of animals constancy of glomerular filtration rate (GFR) and renal blood flow (RBF) was observed after substantial decreases in RAP to a range of 70 to 90 mmHg. These studies therefore do not provide evidence in support of a role for angiotensin II, prostaglandins, or an intrarenal beta receptor as mediators of the renal autoregulation of GFR or total RBF.

Original languageEnglish (US)
Title of host publicationAmerican Journal of Physiology
Pages731-736
Number of pages6
Volume229
Edition3
StatePublished - 1975

Fingerprint

Angiotensin II
Adrenergic Agents
Prostaglandins
Homeostasis
Kidney
Renal Circulation
Glomerular Filtration Rate
Arterial Pressure
Meclofenamic Acid
Adrenergic beta-Antagonists
Prostaglandin-Endoperoxide Synthases
Renin-Angiotensin System
Renin
Propranolol
Indomethacin
Glycine
Dogs

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Anderson, R. J., Taher, M. S., Cronin, R. E., McDonald, K. M., & Schrier, R. W. (1975). Effect of β adrenergic blockade and inhibitors of angiotensin II and prostaglandins on renal autoregulation. In American Journal of Physiology (3 ed., Vol. 229, pp. 731-736)

Effect of β adrenergic blockade and inhibitors of angiotensin II and prostaglandins on renal autoregulation. / Anderson, R. J.; Taher, M. S.; Cronin, R. E.; McDonald, K. M.; Schrier, R. W.

American Journal of Physiology. Vol. 229 3. ed. 1975. p. 731-736.

Research output: Chapter in Book/Report/Conference proceedingChapter

Anderson, RJ, Taher, MS, Cronin, RE, McDonald, KM & Schrier, RW 1975, Effect of β adrenergic blockade and inhibitors of angiotensin II and prostaglandins on renal autoregulation. in American Journal of Physiology. 3 edn, vol. 229, pp. 731-736.
Anderson RJ, Taher MS, Cronin RE, McDonald KM, Schrier RW. Effect of β adrenergic blockade and inhibitors of angiotensin II and prostaglandins on renal autoregulation. In American Journal of Physiology. 3 ed. Vol. 229. 1975. p. 731-736
Anderson, R. J. ; Taher, M. S. ; Cronin, R. E. ; McDonald, K. M. ; Schrier, R. W. / Effect of β adrenergic blockade and inhibitors of angiotensin II and prostaglandins on renal autoregulation. American Journal of Physiology. Vol. 229 3. ed. 1975. pp. 731-736
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