Effect of γ interferon on cachectin expression by mononuclear phagocytes. Reversal of the lps(d) (endotoxin resistance) phenotype

B. Beutler, V. Tkacenko, I. Milsark, N. Krochin, A. Cerami

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180 Citations (Scopus)

Abstract

IFN-γ permits the endotoxin-induced production of cachectin by C3H/HeJ (endotoxin resistant) macrophages, apparently by facilitating endotoxin-induced cachectin biosynthesis at both transcriptional and posttranscriptional levels. IFN-γ cannot induce cachectin biosynthesis by itself, nor does it markedly enhance cachectin production by endotoxin-induced peritoneal macrophages obtained from endotoxin-responsive mice. Elucidation of the precise mechanism through which IFN-γ influences cachectin biosynthesis may permit a better understanding of the molecular events that follow endotoxin-induced activation of macrophages. Moreover, the permissive effect of IFN-γ on cachectin biosynthesis might elicit enhanced endotoxin sensitivity in vivo.

Original languageEnglish (US)
Pages (from-to)1791-1796
Number of pages6
JournalJournal of Experimental Medicine
Volume164
Issue number5
DOIs
StatePublished - 1986

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Phagocytes
Endotoxins
Interferons
Tumor Necrosis Factor-alpha
Phenotype
Macrophage Activation
Peritoneal Macrophages
Macrophages

ASJC Scopus subject areas

  • Immunology

Cite this

Effect of γ interferon on cachectin expression by mononuclear phagocytes. Reversal of the lps(d) (endotoxin resistance) phenotype. / Beutler, B.; Tkacenko, V.; Milsark, I.; Krochin, N.; Cerami, A.

In: Journal of Experimental Medicine, Vol. 164, No. 5, 1986, p. 1791-1796.

Research output: Contribution to journalArticle

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