Effect of 1,25-(OH)2D3 on jejunal absorption of magnesium in patients with chronic renal disease.

A. C. Schmulen, M. Lerman, C. Y. Pak, J. Zerwekh, S. Morawski, J. S. Fordtran, P. Vergne-Marini

Research output: Contribution to journalArticle

31 Scopus citations

Abstract

These studies were performed to see if jejunal malabsorption of magnesium in patients with chronic renal disease was influenced by therapy with 1 alpha, 25-dihydroxyvitamin D3 [1,25-(OH)2D3; 2 microgram/day by mouth for 7 days]. This treatment restored normal serum concentrations of the vitamin D metabolite from 0.9 +/- 0.2 to 4.2 +/- 0.6 ng/dl. Jejunal absorption of magnesium, measured by a triple-lumen constant-perfusion technique, was enhanced in each of the seven patients by this therapy. The mean value rose from 0.04 +/- 0.02 to 0.13 +/- 0.02 mmol . 30 cm-1 . h-1. This last value is similar to the magnesium absorption rate in untreated normal subjects. These results demonstrate that magnesium absorption in the human jejunum is dependent on vitamin D, and they show that 1 alpha,25-dihydroxyvitamin D3 therapy in patients with chronic renal failure is associated with an enhanced jejunal absorption of magnesium.

Original languageEnglish (US)
Pages (from-to)G349-352
JournalThe American journal of physiology
Volume238
Issue number4
StatePublished - Apr 1 1980

ASJC Scopus subject areas

  • Physiology (medical)

Fingerprint Dive into the research topics of 'Effect of 1,25-(OH)2D3 on jejunal absorption of magnesium in patients with chronic renal disease.'. Together they form a unique fingerprint.

  • Cite this

    Schmulen, A. C., Lerman, M., Pak, C. Y., Zerwekh, J., Morawski, S., Fordtran, J. S., & Vergne-Marini, P. (1980). Effect of 1,25-(OH)2D3 on jejunal absorption of magnesium in patients with chronic renal disease. The American journal of physiology, 238(4), G349-352.