Effect of a high-carbohydrate versus a high - cis-monounsaturated fat diet on blood pressure in patients with type 2 diabetes

Meena Shah, Beverley Adams-Huet, John P. Bantle, Robert R. Henry, Kay A. Griver, Susan K. Raatz, Linda J. Brinkley, Gerald M. Reaven, Abhimanyu Garg

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Abstract

OBJECTIVE - To investigate whether blood pressure is different in type 2 diabetic patients on a diet rich in carbohydrates versus a diet rich in cis-monounsaturated fatty acids. Data on the dietary effects on these diets' glucose and lipid metabolism have been previously published. RESEARCH DESIGN AND METHODS - The study compared the effect of feeding 42 type 2 diabetic patients a carefully controlled isoenergic high-carbohydrate (high-carb; 55% energy as carbohydrate, 30% as fat, and 10% as monounsaturated fat) and high-monounsaturated fat (high-mono; 45% energy as fat, 25% as monounsaturated fat, and 40% as carbohydrate) diet for 6 weeks each in a four-center, randomized, cross-over study on blood pressure. Twenty-one patients continued the diet they received during the second phase for an additional 8 weeks. RESULTS - According to repeated-measures ANOVA, blood pressure during the last 3 days of each phase was similar after 6 weeks of the high-carb and high-mono diets (systolic blood pressure: 128 ± 16 vs. 127 ± 15 mmHg, P = 0.9; diastolic blood pressure: 75 ± 7 vs. 75 ± 8 mmHg, P = 0.7). However, after 14 weeks of the high-carb diet (n = 13), there was a significant increase in blood pressure compared with 6 weeks of the high-mono diet (systolic blood pressure: 132 ± 13 vs. 126 ± 11 mmHg, P = 0.04; diastolic blood pressure: 83 ± 6 vs. 76 ± 7 mmHg, P = 0.002). After 14 weeks of the high-mono diet (n = 8), the reduction in blood pressure was not significant compared with 6 weeks of the high-carb diet (systolic blood pressure: 118 ± 14 vs. 121 ± 16 mmHg, P = 0.4; diastolic blood pressure: 71 ± 8 vs. 75 ± 10 mmHg, P = 0.3). CONCLUSION - Although the exchange of carbohydrates with monounsaturated fats may not affect blood pressure in the short term, long-term consumption of a high-carbohydrate diet may modestly raise blood pressure in type 2 diabetic patients.

Original languageEnglish (US)
Pages (from-to)2607-2612
Number of pages6
JournalDiabetes Care
Volume28
Issue number11
DOIs
StatePublished - 2005

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Type 2 Diabetes Mellitus
Fats
Carbohydrates
Diet
Blood Pressure
Monounsaturated Fatty Acids
Lipid Metabolism
Cross-Over Studies

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism

Cite this

Effect of a high-carbohydrate versus a high - cis-monounsaturated fat diet on blood pressure in patients with type 2 diabetes. / Shah, Meena; Adams-Huet, Beverley; Bantle, John P.; Henry, Robert R.; Griver, Kay A.; Raatz, Susan K.; Brinkley, Linda J.; Reaven, Gerald M.; Garg, Abhimanyu.

In: Diabetes Care, Vol. 28, No. 11, 2005, p. 2607-2612.

Research output: Contribution to journalArticle

Shah, M, Adams-Huet, B, Bantle, JP, Henry, RR, Griver, KA, Raatz, SK, Brinkley, LJ, Reaven, GM & Garg, A 2005, 'Effect of a high-carbohydrate versus a high - cis-monounsaturated fat diet on blood pressure in patients with type 2 diabetes', Diabetes Care, vol. 28, no. 11, pp. 2607-2612. https://doi.org/10.2337/diacare.28.11.2607
Shah, Meena ; Adams-Huet, Beverley ; Bantle, John P. ; Henry, Robert R. ; Griver, Kay A. ; Raatz, Susan K. ; Brinkley, Linda J. ; Reaven, Gerald M. ; Garg, Abhimanyu. / Effect of a high-carbohydrate versus a high - cis-monounsaturated fat diet on blood pressure in patients with type 2 diabetes. In: Diabetes Care. 2005 ; Vol. 28, No. 11. pp. 2607-2612.
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title = "Effect of a high-carbohydrate versus a high - cis-monounsaturated fat diet on blood pressure in patients with type 2 diabetes",
abstract = "OBJECTIVE - To investigate whether blood pressure is different in type 2 diabetic patients on a diet rich in carbohydrates versus a diet rich in cis-monounsaturated fatty acids. Data on the dietary effects on these diets' glucose and lipid metabolism have been previously published. RESEARCH DESIGN AND METHODS - The study compared the effect of feeding 42 type 2 diabetic patients a carefully controlled isoenergic high-carbohydrate (high-carb; 55{\%} energy as carbohydrate, 30{\%} as fat, and 10{\%} as monounsaturated fat) and high-monounsaturated fat (high-mono; 45{\%} energy as fat, 25{\%} as monounsaturated fat, and 40{\%} as carbohydrate) diet for 6 weeks each in a four-center, randomized, cross-over study on blood pressure. Twenty-one patients continued the diet they received during the second phase for an additional 8 weeks. RESULTS - According to repeated-measures ANOVA, blood pressure during the last 3 days of each phase was similar after 6 weeks of the high-carb and high-mono diets (systolic blood pressure: 128 ± 16 vs. 127 ± 15 mmHg, P = 0.9; diastolic blood pressure: 75 ± 7 vs. 75 ± 8 mmHg, P = 0.7). However, after 14 weeks of the high-carb diet (n = 13), there was a significant increase in blood pressure compared with 6 weeks of the high-mono diet (systolic blood pressure: 132 ± 13 vs. 126 ± 11 mmHg, P = 0.04; diastolic blood pressure: 83 ± 6 vs. 76 ± 7 mmHg, P = 0.002). After 14 weeks of the high-mono diet (n = 8), the reduction in blood pressure was not significant compared with 6 weeks of the high-carb diet (systolic blood pressure: 118 ± 14 vs. 121 ± 16 mmHg, P = 0.4; diastolic blood pressure: 71 ± 8 vs. 75 ± 10 mmHg, P = 0.3). CONCLUSION - Although the exchange of carbohydrates with monounsaturated fats may not affect blood pressure in the short term, long-term consumption of a high-carbohydrate diet may modestly raise blood pressure in type 2 diabetic patients.",
author = "Meena Shah and Beverley Adams-Huet and Bantle, {John P.} and Henry, {Robert R.} and Griver, {Kay A.} and Raatz, {Susan K.} and Brinkley, {Linda J.} and Reaven, {Gerald M.} and Abhimanyu Garg",
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T1 - Effect of a high-carbohydrate versus a high - cis-monounsaturated fat diet on blood pressure in patients with type 2 diabetes

AU - Shah, Meena

AU - Adams-Huet, Beverley

AU - Bantle, John P.

AU - Henry, Robert R.

AU - Griver, Kay A.

AU - Raatz, Susan K.

AU - Brinkley, Linda J.

AU - Reaven, Gerald M.

AU - Garg, Abhimanyu

PY - 2005

Y1 - 2005

N2 - OBJECTIVE - To investigate whether blood pressure is different in type 2 diabetic patients on a diet rich in carbohydrates versus a diet rich in cis-monounsaturated fatty acids. Data on the dietary effects on these diets' glucose and lipid metabolism have been previously published. RESEARCH DESIGN AND METHODS - The study compared the effect of feeding 42 type 2 diabetic patients a carefully controlled isoenergic high-carbohydrate (high-carb; 55% energy as carbohydrate, 30% as fat, and 10% as monounsaturated fat) and high-monounsaturated fat (high-mono; 45% energy as fat, 25% as monounsaturated fat, and 40% as carbohydrate) diet for 6 weeks each in a four-center, randomized, cross-over study on blood pressure. Twenty-one patients continued the diet they received during the second phase for an additional 8 weeks. RESULTS - According to repeated-measures ANOVA, blood pressure during the last 3 days of each phase was similar after 6 weeks of the high-carb and high-mono diets (systolic blood pressure: 128 ± 16 vs. 127 ± 15 mmHg, P = 0.9; diastolic blood pressure: 75 ± 7 vs. 75 ± 8 mmHg, P = 0.7). However, after 14 weeks of the high-carb diet (n = 13), there was a significant increase in blood pressure compared with 6 weeks of the high-mono diet (systolic blood pressure: 132 ± 13 vs. 126 ± 11 mmHg, P = 0.04; diastolic blood pressure: 83 ± 6 vs. 76 ± 7 mmHg, P = 0.002). After 14 weeks of the high-mono diet (n = 8), the reduction in blood pressure was not significant compared with 6 weeks of the high-carb diet (systolic blood pressure: 118 ± 14 vs. 121 ± 16 mmHg, P = 0.4; diastolic blood pressure: 71 ± 8 vs. 75 ± 10 mmHg, P = 0.3). CONCLUSION - Although the exchange of carbohydrates with monounsaturated fats may not affect blood pressure in the short term, long-term consumption of a high-carbohydrate diet may modestly raise blood pressure in type 2 diabetic patients.

AB - OBJECTIVE - To investigate whether blood pressure is different in type 2 diabetic patients on a diet rich in carbohydrates versus a diet rich in cis-monounsaturated fatty acids. Data on the dietary effects on these diets' glucose and lipid metabolism have been previously published. RESEARCH DESIGN AND METHODS - The study compared the effect of feeding 42 type 2 diabetic patients a carefully controlled isoenergic high-carbohydrate (high-carb; 55% energy as carbohydrate, 30% as fat, and 10% as monounsaturated fat) and high-monounsaturated fat (high-mono; 45% energy as fat, 25% as monounsaturated fat, and 40% as carbohydrate) diet for 6 weeks each in a four-center, randomized, cross-over study on blood pressure. Twenty-one patients continued the diet they received during the second phase for an additional 8 weeks. RESULTS - According to repeated-measures ANOVA, blood pressure during the last 3 days of each phase was similar after 6 weeks of the high-carb and high-mono diets (systolic blood pressure: 128 ± 16 vs. 127 ± 15 mmHg, P = 0.9; diastolic blood pressure: 75 ± 7 vs. 75 ± 8 mmHg, P = 0.7). However, after 14 weeks of the high-carb diet (n = 13), there was a significant increase in blood pressure compared with 6 weeks of the high-mono diet (systolic blood pressure: 132 ± 13 vs. 126 ± 11 mmHg, P = 0.04; diastolic blood pressure: 83 ± 6 vs. 76 ± 7 mmHg, P = 0.002). After 14 weeks of the high-mono diet (n = 8), the reduction in blood pressure was not significant compared with 6 weeks of the high-carb diet (systolic blood pressure: 118 ± 14 vs. 121 ± 16 mmHg, P = 0.4; diastolic blood pressure: 71 ± 8 vs. 75 ± 10 mmHg, P = 0.3). CONCLUSION - Although the exchange of carbohydrates with monounsaturated fats may not affect blood pressure in the short term, long-term consumption of a high-carbohydrate diet may modestly raise blood pressure in type 2 diabetic patients.

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