Effect of a high-carbohydrate vs a high-cis-monounsaturated fat diet on lipid and lipoproteins in individuals with and without type 2 diabetes

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Abstract

It is not known whether the extent of the improvement in lipids and lipoproteins on a high-cis-monounsaturated (high-mono) diet compared with a high-carbohydrate (high-carb) diet is different in patients with type 2 diabetes mellitus (T2DM) and nondiabetic subjects. The aim of this study is to compare the effect of a high-mono and a high-carb diet on lipids and lipoproteins in patients with T2DM and nondiabetic subjects. Ten healthy nondiabetic men, 8 men with T2DM on dietary therapy alone, and 10 men with T2DM requiring insulin therapy were fed an isoenergic high-carb diet (60% energy as carbohydrate and 25% as fat) and a high-mono diet (50% energy as fat and 35% as carbohydrate) for 2 to 4 weeks in a randomized, crossover fashion. Dietary fiber, simple carbohydrates, and cholesterol were held constant across diets. The lipid and lipoprotein responses to these diets were compared in nondiabetic and T2DM subjects by repeated measures analysis of variance model. Patients with T2DM had 2.2 to 2.3 times greater reductions in plasma triacylglycerol, very low-density lipoprotein (VLDL) cholesterol, and total cholesterol/high-density lipoprotein cholesterol ratio (TC/HDLC) on the high-mono diet compared with the high-carb diet than the nondiabetic subjects (P =. 02-.04). The reductions in triacylglycerol and VLDL cholesterol were 2.7 times greater (P =. 009-.02) in T2DM subjects with high plasma triacylglycerol concentrations (>2.26 mmol/L) but only 1.4 to 2.0 times greater (P =. 16-.52) in T2DM patients with low triacylglycerol concentrations (<2.26 mmol/L) compared with nondiabetic subjects who all had low triacylglycerol concentrations (<2.26 mmol/L). Patients with T2DM experienced greater decreases in plasma triacylglycerol, VLDL cholesterol, and TC/HDLC on a high-mono diet compared with a high-carb diet than nondiabetic subjects. The extents of the improvements were likely related to plasma triacylglycerol concentrations in patients with T2DM.

Original languageEnglish (US)
Pages (from-to)969-979
Number of pages11
JournalNutrition Research
Volume24
Issue number12
DOIs
StatePublished - Dec 2004

Fingerprint

Type 2 Diabetes Mellitus
Lipoproteins
Fats
Carbohydrates
Diet
Lipids
Triglycerides
VLDL Cholesterol
Cholesterol
HDL Cholesterol
Dietary Fiber
Analysis of Variance
Insulin
Therapeutics

Keywords

  • Diabetic subjects
  • High-carbohydrate diet
  • High-monounsaturated diet
  • Lipids and lipoproteins
  • Nondiabetic subjects

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

Cite this

@article{7c5bd559f808456fbeb7b8d3627e9e8c,
title = "Effect of a high-carbohydrate vs a high-cis-monounsaturated fat diet on lipid and lipoproteins in individuals with and without type 2 diabetes",
abstract = "It is not known whether the extent of the improvement in lipids and lipoproteins on a high-cis-monounsaturated (high-mono) diet compared with a high-carbohydrate (high-carb) diet is different in patients with type 2 diabetes mellitus (T2DM) and nondiabetic subjects. The aim of this study is to compare the effect of a high-mono and a high-carb diet on lipids and lipoproteins in patients with T2DM and nondiabetic subjects. Ten healthy nondiabetic men, 8 men with T2DM on dietary therapy alone, and 10 men with T2DM requiring insulin therapy were fed an isoenergic high-carb diet (60{\%} energy as carbohydrate and 25{\%} as fat) and a high-mono diet (50{\%} energy as fat and 35{\%} as carbohydrate) for 2 to 4 weeks in a randomized, crossover fashion. Dietary fiber, simple carbohydrates, and cholesterol were held constant across diets. The lipid and lipoprotein responses to these diets were compared in nondiabetic and T2DM subjects by repeated measures analysis of variance model. Patients with T2DM had 2.2 to 2.3 times greater reductions in plasma triacylglycerol, very low-density lipoprotein (VLDL) cholesterol, and total cholesterol/high-density lipoprotein cholesterol ratio (TC/HDLC) on the high-mono diet compared with the high-carb diet than the nondiabetic subjects (P =. 02-.04). The reductions in triacylglycerol and VLDL cholesterol were 2.7 times greater (P =. 009-.02) in T2DM subjects with high plasma triacylglycerol concentrations (>2.26 mmol/L) but only 1.4 to 2.0 times greater (P =. 16-.52) in T2DM patients with low triacylglycerol concentrations (<2.26 mmol/L) compared with nondiabetic subjects who all had low triacylglycerol concentrations (<2.26 mmol/L). Patients with T2DM experienced greater decreases in plasma triacylglycerol, VLDL cholesterol, and TC/HDLC on a high-mono diet compared with a high-carb diet than nondiabetic subjects. The extents of the improvements were likely related to plasma triacylglycerol concentrations in patients with T2DM.",
keywords = "Diabetic subjects, High-carbohydrate diet, High-monounsaturated diet, Lipids and lipoproteins, Nondiabetic subjects",
author = "Meena Shah and Huet, {Beverley A} and Grundy, {Scott M} and Abhimanyu Garg",
year = "2004",
month = "12",
doi = "10.1016/j.nutres.2004.08.001",
language = "English (US)",
volume = "24",
pages = "969--979",
journal = "Nutrition Research",
issn = "0271-5317",
publisher = "Elsevier Inc.",
number = "12",

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TY - JOUR

T1 - Effect of a high-carbohydrate vs a high-cis-monounsaturated fat diet on lipid and lipoproteins in individuals with and without type 2 diabetes

AU - Shah, Meena

AU - Huet, Beverley A

AU - Grundy, Scott M

AU - Garg, Abhimanyu

PY - 2004/12

Y1 - 2004/12

N2 - It is not known whether the extent of the improvement in lipids and lipoproteins on a high-cis-monounsaturated (high-mono) diet compared with a high-carbohydrate (high-carb) diet is different in patients with type 2 diabetes mellitus (T2DM) and nondiabetic subjects. The aim of this study is to compare the effect of a high-mono and a high-carb diet on lipids and lipoproteins in patients with T2DM and nondiabetic subjects. Ten healthy nondiabetic men, 8 men with T2DM on dietary therapy alone, and 10 men with T2DM requiring insulin therapy were fed an isoenergic high-carb diet (60% energy as carbohydrate and 25% as fat) and a high-mono diet (50% energy as fat and 35% as carbohydrate) for 2 to 4 weeks in a randomized, crossover fashion. Dietary fiber, simple carbohydrates, and cholesterol were held constant across diets. The lipid and lipoprotein responses to these diets were compared in nondiabetic and T2DM subjects by repeated measures analysis of variance model. Patients with T2DM had 2.2 to 2.3 times greater reductions in plasma triacylglycerol, very low-density lipoprotein (VLDL) cholesterol, and total cholesterol/high-density lipoprotein cholesterol ratio (TC/HDLC) on the high-mono diet compared with the high-carb diet than the nondiabetic subjects (P =. 02-.04). The reductions in triacylglycerol and VLDL cholesterol were 2.7 times greater (P =. 009-.02) in T2DM subjects with high plasma triacylglycerol concentrations (>2.26 mmol/L) but only 1.4 to 2.0 times greater (P =. 16-.52) in T2DM patients with low triacylglycerol concentrations (<2.26 mmol/L) compared with nondiabetic subjects who all had low triacylglycerol concentrations (<2.26 mmol/L). Patients with T2DM experienced greater decreases in plasma triacylglycerol, VLDL cholesterol, and TC/HDLC on a high-mono diet compared with a high-carb diet than nondiabetic subjects. The extents of the improvements were likely related to plasma triacylglycerol concentrations in patients with T2DM.

AB - It is not known whether the extent of the improvement in lipids and lipoproteins on a high-cis-monounsaturated (high-mono) diet compared with a high-carbohydrate (high-carb) diet is different in patients with type 2 diabetes mellitus (T2DM) and nondiabetic subjects. The aim of this study is to compare the effect of a high-mono and a high-carb diet on lipids and lipoproteins in patients with T2DM and nondiabetic subjects. Ten healthy nondiabetic men, 8 men with T2DM on dietary therapy alone, and 10 men with T2DM requiring insulin therapy were fed an isoenergic high-carb diet (60% energy as carbohydrate and 25% as fat) and a high-mono diet (50% energy as fat and 35% as carbohydrate) for 2 to 4 weeks in a randomized, crossover fashion. Dietary fiber, simple carbohydrates, and cholesterol were held constant across diets. The lipid and lipoprotein responses to these diets were compared in nondiabetic and T2DM subjects by repeated measures analysis of variance model. Patients with T2DM had 2.2 to 2.3 times greater reductions in plasma triacylglycerol, very low-density lipoprotein (VLDL) cholesterol, and total cholesterol/high-density lipoprotein cholesterol ratio (TC/HDLC) on the high-mono diet compared with the high-carb diet than the nondiabetic subjects (P =. 02-.04). The reductions in triacylglycerol and VLDL cholesterol were 2.7 times greater (P =. 009-.02) in T2DM subjects with high plasma triacylglycerol concentrations (>2.26 mmol/L) but only 1.4 to 2.0 times greater (P =. 16-.52) in T2DM patients with low triacylglycerol concentrations (<2.26 mmol/L) compared with nondiabetic subjects who all had low triacylglycerol concentrations (<2.26 mmol/L). Patients with T2DM experienced greater decreases in plasma triacylglycerol, VLDL cholesterol, and TC/HDLC on a high-mono diet compared with a high-carb diet than nondiabetic subjects. The extents of the improvements were likely related to plasma triacylglycerol concentrations in patients with T2DM.

KW - Diabetic subjects

KW - High-carbohydrate diet

KW - High-monounsaturated diet

KW - Lipids and lipoproteins

KW - Nondiabetic subjects

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U2 - 10.1016/j.nutres.2004.08.001

DO - 10.1016/j.nutres.2004.08.001

M3 - Article

AN - SCOPUS:10444251037

VL - 24

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JO - Nutrition Research

JF - Nutrition Research

SN - 0271-5317

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