Effect of age on gastric acid secretion and serum gastrin concentrations in healthy men and women

Markus Goldschmiedt, Cora C. Barnett, Barry E. Schwarz, William E. Karnes, Jan S. Redfern, Mark Feldman

Research output: Contribution to journalArticle

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Abstract

The effects of age on basal, meal-stimulated, and human gastrin-17-stimulated gastric acid secretion rates and serum pepsinogen concentrations were evaluated in 41 healthy men and women. Older subjects (ages 44-71 years; mean, 57 years) had higher mean basal, meal-stimulated, and gastrin-17-stimulated acid secretory rates and basal serum pepsinogen I and II concentrations than younger subjects (ages 23-42 years; mean, 33 years). Age-related differences in acid secretion were especially prominent in men, and age-related differences in serum pepsinogen I and II concentrations were more prominent in women. Higher gastric acid secretion rates in older subjects could not be explained by body size (height, weight, body surface area, or fat-free body mass) or by the higher incidence of infection with Helicobacter pylori. Using a multivariate linear regression model, age had an independent positive effect on acid secretion, and H. pylori infection had an independent negative effect. It was concluded that aging is associated with an increase in gastric acid secretion in humans, especially in men, while infection with H. pylori is associated with lower acid secretion rates.

Original languageEnglish (US)
Pages (from-to)977-990
Number of pages14
JournalGastroenterology
Volume101
Issue number4
StatePublished - 1991

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Gastric Acid
Gastrins
Pepsinogen A
Pepsinogen C
Helicobacter pylori
Acids
Serum
Meals
Linear Models
Secretory Rate
Body Height
Body Surface Area
Body Size
Helicobacter Infections
Infection
Fats
Weights and Measures
Incidence
gastrin 17

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Goldschmiedt, M., Barnett, C. C., Schwarz, B. E., Karnes, W. E., Redfern, J. S., & Feldman, M. (1991). Effect of age on gastric acid secretion and serum gastrin concentrations in healthy men and women. Gastroenterology, 101(4), 977-990.

Effect of age on gastric acid secretion and serum gastrin concentrations in healthy men and women. / Goldschmiedt, Markus; Barnett, Cora C.; Schwarz, Barry E.; Karnes, William E.; Redfern, Jan S.; Feldman, Mark.

In: Gastroenterology, Vol. 101, No. 4, 1991, p. 977-990.

Research output: Contribution to journalArticle

Goldschmiedt, M, Barnett, CC, Schwarz, BE, Karnes, WE, Redfern, JS & Feldman, M 1991, 'Effect of age on gastric acid secretion and serum gastrin concentrations in healthy men and women', Gastroenterology, vol. 101, no. 4, pp. 977-990.
Goldschmiedt M, Barnett CC, Schwarz BE, Karnes WE, Redfern JS, Feldman M. Effect of age on gastric acid secretion and serum gastrin concentrations in healthy men and women. Gastroenterology. 1991;101(4):977-990.
Goldschmiedt, Markus ; Barnett, Cora C. ; Schwarz, Barry E. ; Karnes, William E. ; Redfern, Jan S. ; Feldman, Mark. / Effect of age on gastric acid secretion and serum gastrin concentrations in healthy men and women. In: Gastroenterology. 1991 ; Vol. 101, No. 4. pp. 977-990.
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