Effect of amphetamine, α-methyl-p-tyrosine (α-MPT) and antipsychotic agents on dopamine D2-type receptor occupancy in rats

Robert A. Lahti, Carol A. Tamminga

Research output: Contribution to journalArticle

7 Scopus citations

Abstract

1. EEDQ inactivates unoccupied receptors in vivo in brain tissue and is useful in determining which receptors are occupied by a drug treatment. 2. α-MPT, inhibits the synthesis of dopamine, reducing D2-type receptor occupancy by dopamine and enhances the amount of receptor inactivation by EEDQ. 3. Amphetamine releases dopamine resulting in increased occupancy of dopamine D2-type receptors and we have shown that it protects those receptors from EEDQ. 4. Clozapine and remoxipride, two antipsychotic agents, occupied the dopamine receptors in both the caudate and cortex. 5. These findings are important because they substantiate other results obtained with amphetamine and SPECT, which demonstrated an exaggerated dopamine neurotransmission in schizophrenic patients versus normal controls.

Original languageEnglish (US)
Pages (from-to)1277-1283
Number of pages7
JournalProgress in Neuro-Psychopharmacology and Biological Psychiatry
Volume23
Issue number7
DOIs
StatePublished - Oct 1 1999

Keywords

  • Amphetamine
  • Antipsychotics
  • Dopamine receptor
  • EEDQ
  • Receptor occupancy

ASJC Scopus subject areas

  • Pharmacology
  • Biological Psychiatry

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