Effect of apolipoprotein E genotype on in-hospital mortality following intracerebral haemorrhage

Mark O. McCarron, C. J. Weir, K. W. Muir, K. L. Hoffmann, C. Graffagnino, J. A R Nicoll, K. R. Lees, M. J. Alberts

Research output: Contribution to journalArticle

53 Scopus citations

Abstract

Objective - To determine the relationship between the apolipoprotein E (APOE) ε4 allele and in-hospital mortality from intracerebral haemorrhage (ICH). Material and methods - Patients admitted to two acute stroke units with ICH were prospectively evaluated and APOE genotyped. In-hospital survival was recorded in 176 patients. Results - There were 85 men and 91 women, mean age 68 years. Fifty-two (30%) of the 176 patients died in hospital. After adjusting for sex, age, hospital, and race, increased age (P = 0.009) and the presence of the APOE ε4 allele (P = 0.026) significantly reduced in-hospital survival. Conclusion - The APOE ε4 allele in this population may be associated with poor survival following ICH.

Original languageEnglish (US)
Pages (from-to)106-109
Number of pages4
JournalActa Neurologica Scandinavica
Volume107
Issue number2
DOIs
StatePublished - Feb 1 2003

Keywords

  • Apolipoprotein E
  • Intracerebral haemorrhage
  • Outcome
  • Survival

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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    McCarron, M. O., Weir, C. J., Muir, K. W., Hoffmann, K. L., Graffagnino, C., Nicoll, J. A. R., Lees, K. R., & Alberts, M. J. (2003). Effect of apolipoprotein E genotype on in-hospital mortality following intracerebral haemorrhage. Acta Neurologica Scandinavica, 107(2), 106-109. https://doi.org/10.1034/j.1600-0404.2003.01365.x