Effect of apolipoprotein E genotype on in-hospital mortality following intracerebral haemorrhage

Mark O. McCarron, C. J. Weir, K. W. Muir, K. L. Hoffmann, C. Graffagnino, J. A R Nicoll, K. R. Lees, M. J. Alberts

Research output: Contribution to journalArticle

53 Citations (Scopus)

Abstract

Objective - To determine the relationship between the apolipoprotein E (APOE) ε4 allele and in-hospital mortality from intracerebral haemorrhage (ICH). Material and methods - Patients admitted to two acute stroke units with ICH were prospectively evaluated and APOE genotyped. In-hospital survival was recorded in 176 patients. Results - There were 85 men and 91 women, mean age 68 years. Fifty-two (30%) of the 176 patients died in hospital. After adjusting for sex, age, hospital, and race, increased age (P = 0.009) and the presence of the APOE ε4 allele (P = 0.026) significantly reduced in-hospital survival. Conclusion - The APOE ε4 allele in this population may be associated with poor survival following ICH.

Original languageEnglish (US)
Pages (from-to)106-109
Number of pages4
JournalActa Neurologica Scandinavica
Volume107
Issue number2
DOIs
StatePublished - Feb 1 2003

Fingerprint

Cerebral Hemorrhage
Apolipoproteins E
Hospital Mortality
Apolipoprotein E4
Genotype
Alleles
Survival
Stroke
Population

Keywords

  • Apolipoprotein E
  • Intracerebral haemorrhage
  • Outcome
  • Survival

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

Cite this

Effect of apolipoprotein E genotype on in-hospital mortality following intracerebral haemorrhage. / McCarron, Mark O.; Weir, C. J.; Muir, K. W.; Hoffmann, K. L.; Graffagnino, C.; Nicoll, J. A R; Lees, K. R.; Alberts, M. J.

In: Acta Neurologica Scandinavica, Vol. 107, No. 2, 01.02.2003, p. 106-109.

Research output: Contribution to journalArticle

McCarron, MO, Weir, CJ, Muir, KW, Hoffmann, KL, Graffagnino, C, Nicoll, JAR, Lees, KR & Alberts, MJ 2003, 'Effect of apolipoprotein E genotype on in-hospital mortality following intracerebral haemorrhage', Acta Neurologica Scandinavica, vol. 107, no. 2, pp. 106-109. https://doi.org/10.1034/j.1600-0404.2003.01365.x
McCarron, Mark O. ; Weir, C. J. ; Muir, K. W. ; Hoffmann, K. L. ; Graffagnino, C. ; Nicoll, J. A R ; Lees, K. R. ; Alberts, M. J. / Effect of apolipoprotein E genotype on in-hospital mortality following intracerebral haemorrhage. In: Acta Neurologica Scandinavica. 2003 ; Vol. 107, No. 2. pp. 106-109.
@article{59dffcfb3dac47f982920c293a6f8f88,
title = "Effect of apolipoprotein E genotype on in-hospital mortality following intracerebral haemorrhage",
abstract = "Objective - To determine the relationship between the apolipoprotein E (APOE) ε4 allele and in-hospital mortality from intracerebral haemorrhage (ICH). Material and methods - Patients admitted to two acute stroke units with ICH were prospectively evaluated and APOE genotyped. In-hospital survival was recorded in 176 patients. Results - There were 85 men and 91 women, mean age 68 years. Fifty-two (30{\%}) of the 176 patients died in hospital. After adjusting for sex, age, hospital, and race, increased age (P = 0.009) and the presence of the APOE ε4 allele (P = 0.026) significantly reduced in-hospital survival. Conclusion - The APOE ε4 allele in this population may be associated with poor survival following ICH.",
keywords = "Apolipoprotein E, Intracerebral haemorrhage, Outcome, Survival",
author = "McCarron, {Mark O.} and Weir, {C. J.} and Muir, {K. W.} and Hoffmann, {K. L.} and C. Graffagnino and Nicoll, {J. A R} and Lees, {K. R.} and Alberts, {M. J.}",
year = "2003",
month = "2",
day = "1",
doi = "10.1034/j.1600-0404.2003.01365.x",
language = "English (US)",
volume = "107",
pages = "106--109",
journal = "Acta Neurologica Scandinavica",
issn = "0001-6314",
publisher = "Wiley-Blackwell",
number = "2",

}

TY - JOUR

T1 - Effect of apolipoprotein E genotype on in-hospital mortality following intracerebral haemorrhage

AU - McCarron, Mark O.

AU - Weir, C. J.

AU - Muir, K. W.

AU - Hoffmann, K. L.

AU - Graffagnino, C.

AU - Nicoll, J. A R

AU - Lees, K. R.

AU - Alberts, M. J.

PY - 2003/2/1

Y1 - 2003/2/1

N2 - Objective - To determine the relationship between the apolipoprotein E (APOE) ε4 allele and in-hospital mortality from intracerebral haemorrhage (ICH). Material and methods - Patients admitted to two acute stroke units with ICH were prospectively evaluated and APOE genotyped. In-hospital survival was recorded in 176 patients. Results - There were 85 men and 91 women, mean age 68 years. Fifty-two (30%) of the 176 patients died in hospital. After adjusting for sex, age, hospital, and race, increased age (P = 0.009) and the presence of the APOE ε4 allele (P = 0.026) significantly reduced in-hospital survival. Conclusion - The APOE ε4 allele in this population may be associated with poor survival following ICH.

AB - Objective - To determine the relationship between the apolipoprotein E (APOE) ε4 allele and in-hospital mortality from intracerebral haemorrhage (ICH). Material and methods - Patients admitted to two acute stroke units with ICH were prospectively evaluated and APOE genotyped. In-hospital survival was recorded in 176 patients. Results - There were 85 men and 91 women, mean age 68 years. Fifty-two (30%) of the 176 patients died in hospital. After adjusting for sex, age, hospital, and race, increased age (P = 0.009) and the presence of the APOE ε4 allele (P = 0.026) significantly reduced in-hospital survival. Conclusion - The APOE ε4 allele in this population may be associated with poor survival following ICH.

KW - Apolipoprotein E

KW - Intracerebral haemorrhage

KW - Outcome

KW - Survival

UR - http://www.scopus.com/inward/record.url?scp=0037292267&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0037292267&partnerID=8YFLogxK

U2 - 10.1034/j.1600-0404.2003.01365.x

DO - 10.1034/j.1600-0404.2003.01365.x

M3 - Article

C2 - 12580859

AN - SCOPUS:0037292267

VL - 107

SP - 106

EP - 109

JO - Acta Neurologica Scandinavica

JF - Acta Neurologica Scandinavica

SN - 0001-6314

IS - 2

ER -