TY - JOUR
T1 - Effect of baseline glycosylated hemoglobin a1c on glycemic control and diabetes management following initiation of once-daily insulin detemir in real-life clinical practice
AU - Caputo, Salvatore
AU - Andersen, Henning
AU - Kaiser, Marcel
AU - Karnieli, Eddy
AU - Meneghini, Luigi F.
AU - Svendsen, Anne Louise
PY - 2013/5/1
Y1 - 2013/5/1
N2 - Objective: The SOLVE study investigate. The initiation of basal insulin in patients with type 2 diabetes on oral antidiabetic (OAD) treatment and outcomes in patients with varying levels of glycemic control at baseline.Methods: This was an observational cohort study conducted in 10 countries using insulin detemir. Data were collected at 3 clinic visits (baseline, 12-week interim, and 24-week final visit).Results: A total of 13,526 (77.9%) patients were included i. The glycosylated hemoglobin A1c (HbA1c) subset analysis. Patients were grouped according to pre-insulin HbA1c values as follows: HbA1c <7.6% (n = 2,797); HbA1c 7.6-9% (n = 5,366), and HbA1c >9% (n = 5,363). A total of 27 patients experienced serious adverse drug reactions (SADRs) and/or severe hypoglycemia (3, 10, and 11 patients with pre-insulin HbA1c <7.6%, 7.6-9.0%, and >9.0%, respectively). All patient subgroups realized improvements in HbA1c, wit. The pre-insulin HbA1c >9% subgroup havin. The largest HbA1c reduction (-2.4% versus -0.9% and -0.2% for HbA1c subgroups 7.6-9% and <7.6%, respectively). I. The total cohort (n = 17,374). The incidence of severe hypoglycemia decreased from 4 events per 100 person years to <1 event per 100 person years by final visit. The incidence of minor hypoglycemia increased from 1.6 to 1.8 events per person year.Conclusions: In this study, insulin initiation was delayed until late in disease course, and overall concordance with internationally recognized guidelines was low. The initiation of once-daily insulin detemir was associated with substantial improvements in glycemic control and was not associated with an increase in severe hypoglycemia or weight gain.
AB - Objective: The SOLVE study investigate. The initiation of basal insulin in patients with type 2 diabetes on oral antidiabetic (OAD) treatment and outcomes in patients with varying levels of glycemic control at baseline.Methods: This was an observational cohort study conducted in 10 countries using insulin detemir. Data were collected at 3 clinic visits (baseline, 12-week interim, and 24-week final visit).Results: A total of 13,526 (77.9%) patients were included i. The glycosylated hemoglobin A1c (HbA1c) subset analysis. Patients were grouped according to pre-insulin HbA1c values as follows: HbA1c <7.6% (n = 2,797); HbA1c 7.6-9% (n = 5,366), and HbA1c >9% (n = 5,363). A total of 27 patients experienced serious adverse drug reactions (SADRs) and/or severe hypoglycemia (3, 10, and 11 patients with pre-insulin HbA1c <7.6%, 7.6-9.0%, and >9.0%, respectively). All patient subgroups realized improvements in HbA1c, wit. The pre-insulin HbA1c >9% subgroup havin. The largest HbA1c reduction (-2.4% versus -0.9% and -0.2% for HbA1c subgroups 7.6-9% and <7.6%, respectively). I. The total cohort (n = 17,374). The incidence of severe hypoglycemia decreased from 4 events per 100 person years to <1 event per 100 person years by final visit. The incidence of minor hypoglycemia increased from 1.6 to 1.8 events per person year.Conclusions: In this study, insulin initiation was delayed until late in disease course, and overall concordance with internationally recognized guidelines was low. The initiation of once-daily insulin detemir was associated with substantial improvements in glycemic control and was not associated with an increase in severe hypoglycemia or weight gain.
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U2 - 10.4158/EP12269.OR
DO - 10.4158/EP12269.OR
M3 - Article
C2 - 23337147
AN - SCOPUS:84880117552
SN - 1530-891X
VL - 19
SP - 462
EP - 470
JO - Endocrine Practice
JF - Endocrine Practice
IS - 3
ER -