We have used the CBA/N X‐linked B‐cell maturation defect (xid) as a probe to analyse the B‐cell subset involved in spontaneous anti‐DNA production in MRL/1 and NZB mice. The presence of xid in NZB offspring significantly suppressed anti‐DNA production, whereas it did not suppress spontaneously produced antibody to DNA in MRL/1 offspring. These studies suggest that largely non‐overlapping B‐cell subsets are responsible for the spontaneous production of anti‐DNA in MRL/1 and NZB mice.
|Original language||English (US)|
|Number of pages||4|
|Journal||Scandinavian Journal of Immunology|
|State||Published - Dec 1980|
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