Effect of CBA/N xid on spontaneous production of antibodies to DNA in MRL/1 and NZB backcross mice

J. S. Cowdery, J. D. Taurog, A. D. Steinberg

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

We have used the CBA/N X-linked B-cell maturation defect (xid) as a probe to analyze the B-cell subset involved in spontaneous anti-DNA production in MRL/1 and NZB mice. The presence of xid in NZB offspring significantly suppressed anti-DNA production, whereas it did not suppress spontaneously produced antibody to DNA in MRL/1 offspring. These studies suggest that largely non-overlapping B-cell subsets are responsible for the spontaneous production of anti-DNA in MRL/1 and NZB mice.

Original languageEnglish (US)
Pages (from-to)499-502
Number of pages4
JournalScandinavian Journal of Immunology
Volume12
Issue number6
StatePublished - 1980

Fingerprint

Inbred NZB Mouse
Antibody Formation
B-Lymphocyte Subsets
DNA
B-Lymphocytes
Antibodies

ASJC Scopus subject areas

  • Immunology

Cite this

Effect of CBA/N xid on spontaneous production of antibodies to DNA in MRL/1 and NZB backcross mice. / Cowdery, J. S.; Taurog, J. D.; Steinberg, A. D.

In: Scandinavian Journal of Immunology, Vol. 12, No. 6, 1980, p. 499-502.

Research output: Contribution to journalArticle

@article{3431cd22b06e41c5ba39a79f19f13aff,
title = "Effect of CBA/N xid on spontaneous production of antibodies to DNA in MRL/1 and NZB backcross mice",
abstract = "We have used the CBA/N X-linked B-cell maturation defect (xid) as a probe to analyze the B-cell subset involved in spontaneous anti-DNA production in MRL/1 and NZB mice. The presence of xid in NZB offspring significantly suppressed anti-DNA production, whereas it did not suppress spontaneously produced antibody to DNA in MRL/1 offspring. These studies suggest that largely non-overlapping B-cell subsets are responsible for the spontaneous production of anti-DNA in MRL/1 and NZB mice.",
author = "Cowdery, {J. S.} and Taurog, {J. D.} and Steinberg, {A. D.}",
year = "1980",
language = "English (US)",
volume = "12",
pages = "499--502",
journal = "Scandinavian Journal of Immunology",
issn = "0300-9475",
publisher = "Wiley-Blackwell",
number = "6",

}

TY - JOUR

T1 - Effect of CBA/N xid on spontaneous production of antibodies to DNA in MRL/1 and NZB backcross mice

AU - Cowdery, J. S.

AU - Taurog, J. D.

AU - Steinberg, A. D.

PY - 1980

Y1 - 1980

N2 - We have used the CBA/N X-linked B-cell maturation defect (xid) as a probe to analyze the B-cell subset involved in spontaneous anti-DNA production in MRL/1 and NZB mice. The presence of xid in NZB offspring significantly suppressed anti-DNA production, whereas it did not suppress spontaneously produced antibody to DNA in MRL/1 offspring. These studies suggest that largely non-overlapping B-cell subsets are responsible for the spontaneous production of anti-DNA in MRL/1 and NZB mice.

AB - We have used the CBA/N X-linked B-cell maturation defect (xid) as a probe to analyze the B-cell subset involved in spontaneous anti-DNA production in MRL/1 and NZB mice. The presence of xid in NZB offspring significantly suppressed anti-DNA production, whereas it did not suppress spontaneously produced antibody to DNA in MRL/1 offspring. These studies suggest that largely non-overlapping B-cell subsets are responsible for the spontaneous production of anti-DNA in MRL/1 and NZB mice.

UR - http://www.scopus.com/inward/record.url?scp=0019208160&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0019208160&partnerID=8YFLogxK

M3 - Article

C2 - 6972569

AN - SCOPUS:0019208160

VL - 12

SP - 499

EP - 502

JO - Scandinavian Journal of Immunology

JF - Scandinavian Journal of Immunology

SN - 0300-9475

IS - 6

ER -