Effect of CBA/N xid on Spontaneous Production of Antibodies to DNA in MRL/1 and NZB Backcross Mice

J. S. Cowdery, J. D. Taurog, A. D. Steinberg

Research output: Contribution to journalArticle

11 Scopus citations

Abstract

We have used the CBA/N X‐linked B‐cell maturation defect (xid) as a probe to analyse the B‐cell subset involved in spontaneous anti‐DNA production in MRL/1 and NZB mice. The presence of xid in NZB offspring significantly suppressed anti‐DNA production, whereas it did not suppress spontaneously produced antibody to DNA in MRL/1 offspring. These studies suggest that largely non‐overlapping B‐cell subsets are responsible for the spontaneous production of anti‐DNA in MRL/1 and NZB mice.

Original languageEnglish (US)
Pages (from-to)499-502
Number of pages4
JournalScandinavian Journal of Immunology
Volume12
Issue number6
DOIs
StatePublished - Dec 1980

ASJC Scopus subject areas

  • Immunology

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