Effect of changes in fat availability on exercise capacity in McArdle disease

Susanne T. Andersen, Tina D. Jeppesen, Tanja Taivassalo, Marie Louise Sveen, Katja Heinicke, Ronald G. Haller, John Vissing

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Background: The major fuel for exercising muscle at low exercise intensities is fat. Objective: To investigate the role of fat metabolism in McArdle disease (also known as glycogen storage disease type V), an inborn error of muscle glycogenolysis, by manipulating free fatty acid availability for oxidation during exercise. Design: Randomized, placebo-controlled, crossover trial. Setting: Hospitalized care. Patients: Ten patients (8 men and 2 women) with McArdle disease. Interventions: Patients cycled at a constant workload corresponding to 70% of their maximum oxygen consumption. In random order and on separate days, patients received nicotinic acid (a known blocker of lipolysis) to decrease the availability of free fatty acids or 20% Intralipid infusion to increase free fatty acid availability during exercise. Results were compared with placebo (isotonic sodium chloride solution infusion) and glucose infusion trials. Main Outcome Measures: Exercise tolerance was assessed by heart rate response to exercise during different infusions. Results: Free fatty acid levels more than tripled by Intralipid infusion and were halved by nicotinic acid administration. Heart rate was significantly higher during exercise in the Intralipid infusion and nicotinic acid trials compared with the placebo and glucose infusion trials, an effect that was observed before and after the patients had experienced the second wind phenomenon. Conclusions: Lipids are an important source of fuel for exercising muscle in McArdle disease, but maximal rates of fat oxidation seem limited and cannot be increased above physiologically normal rates during exercise. This limitation is probably caused by a metabolic bottleneck in the tricarboxylic acid cycle due to impaired glycolytic flux in McArdle disease. Therapies aimed at enhancing fat use in McArdle disease should be combined with interventions targeting expansion of the tricarboxylic acid cycle.

Original languageEnglish (US)
Pages (from-to)762-766
Number of pages5
JournalArchives of Neurology
Volume66
Issue number6
DOIs
StatePublished - Jun 2009

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Glycogen Storage Disease Type V
Fats
Exercise
Nonesterified Fatty Acids
Niacin
Citric Acid Cycle
Placebos
Muscles
Heart Rate
Glycogenolysis
Glucose
Exercise Tolerance
Lipolysis
Workload
Sodium Chloride
Oxygen Consumption
Cross-Over Studies
Fat
Outcome Assessment (Health Care)
Lipids

ASJC Scopus subject areas

  • Clinical Neurology

Cite this

Andersen, S. T., Jeppesen, T. D., Taivassalo, T., Sveen, M. L., Heinicke, K., Haller, R. G., & Vissing, J. (2009). Effect of changes in fat availability on exercise capacity in McArdle disease. Archives of Neurology, 66(6), 762-766. https://doi.org/10.1001/archneurol.2009.93

Effect of changes in fat availability on exercise capacity in McArdle disease. / Andersen, Susanne T.; Jeppesen, Tina D.; Taivassalo, Tanja; Sveen, Marie Louise; Heinicke, Katja; Haller, Ronald G.; Vissing, John.

In: Archives of Neurology, Vol. 66, No. 6, 06.2009, p. 762-766.

Research output: Contribution to journalArticle

Andersen, ST, Jeppesen, TD, Taivassalo, T, Sveen, ML, Heinicke, K, Haller, RG & Vissing, J 2009, 'Effect of changes in fat availability on exercise capacity in McArdle disease', Archives of Neurology, vol. 66, no. 6, pp. 762-766. https://doi.org/10.1001/archneurol.2009.93
Andersen, Susanne T. ; Jeppesen, Tina D. ; Taivassalo, Tanja ; Sveen, Marie Louise ; Heinicke, Katja ; Haller, Ronald G. ; Vissing, John. / Effect of changes in fat availability on exercise capacity in McArdle disease. In: Archives of Neurology. 2009 ; Vol. 66, No. 6. pp. 762-766.
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abstract = "Background: The major fuel for exercising muscle at low exercise intensities is fat. Objective: To investigate the role of fat metabolism in McArdle disease (also known as glycogen storage disease type V), an inborn error of muscle glycogenolysis, by manipulating free fatty acid availability for oxidation during exercise. Design: Randomized, placebo-controlled, crossover trial. Setting: Hospitalized care. Patients: Ten patients (8 men and 2 women) with McArdle disease. Interventions: Patients cycled at a constant workload corresponding to 70{\%} of their maximum oxygen consumption. In random order and on separate days, patients received nicotinic acid (a known blocker of lipolysis) to decrease the availability of free fatty acids or 20{\%} Intralipid infusion to increase free fatty acid availability during exercise. Results were compared with placebo (isotonic sodium chloride solution infusion) and glucose infusion trials. Main Outcome Measures: Exercise tolerance was assessed by heart rate response to exercise during different infusions. Results: Free fatty acid levels more than tripled by Intralipid infusion and were halved by nicotinic acid administration. Heart rate was significantly higher during exercise in the Intralipid infusion and nicotinic acid trials compared with the placebo and glucose infusion trials, an effect that was observed before and after the patients had experienced the second wind phenomenon. Conclusions: Lipids are an important source of fuel for exercising muscle in McArdle disease, but maximal rates of fat oxidation seem limited and cannot be increased above physiologically normal rates during exercise. This limitation is probably caused by a metabolic bottleneck in the tricarboxylic acid cycle due to impaired glycolytic flux in McArdle disease. Therapies aimed at enhancing fat use in McArdle disease should be combined with interventions targeting expansion of the tricarboxylic acid cycle.",
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