Effect of Chemical Deglycosylation on the in vivo Fate of Ricin A-Chain

D. C. Blakey, P. E. Thorpe

Research output: Contribution to journalArticlepeer-review

32 Scopus citations

Abstract

Chemical deglycosylation of ricin A-chain virtually eliminated its entrapment by the liver and delayed its clearance from the bloodstream of mice. Liver entrapment of native ricin A-chain occured to approximately equal extents in the parenchymal and non-parenchymal cell fractions of the liver. The chemical deglycosylation procedure reduced uptake of the A-chain by both cell fractions.

Original languageEnglish (US)
Pages (from-to)189-196
Number of pages8
JournalCancer Drug Delivery
Volume3
Issue number3
DOIs
StatePublished - Jan 1 1986

ASJC Scopus subject areas

  • Pharmacology
  • Cancer Research

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