TY - JOUR
T1 - Effect of chemoradiation on the size of the thyroid gland
AU - Rivas, Ana Marcella
AU - Larumbe-Zabala, Eneko
AU - Diaz-Trastoy, Olaia
AU - Schurr, Ryan Nicholas
AU - Jones, Catherine
AU - Abdulrahman, Ramzi
AU - Dar, Nabeel
AU - Lado-Abeal, Joaquin
N1 - Publisher Copyright:
© 2020, Copyright © 2020 Baylor University Medical Center.
PY - 2020
Y1 - 2020
N2 - We aimed to evaluate changes in thyroid gland size during the treatment of malignancies outside the head and neck with chemotherapy and/or external beam radiation. We performed a retrospective review of records of adult patients treated at our institution with external beam radiation to the chest and/or chemotherapy with taxanes, alkylating agents, and/or a topoisomerase II inhibitor. Neck and chest computed tomography (CT) images were used to calculate thyroid gland volume before and after therapy, using Vitrea® software or the volumetric ellipsoid method. Thirty-seven patients were included. After treatment, there was a significant reduction in thyroid gland volume of 14.0% (P < 0.01) using Vitrea and 17.1% (P < 0.05) using the volumetric ellipsoid method. Exposure to radiation or chemotherapy was not found to be associated with the degree of thyroid gland reduction, nor was the number of days between CT scans or the stage of the malignancy being treated. Finally, the degree of thyroid gland size reduction did not predict mortality. Our results showed that the treatment of malignancies outside the head and neck with chemotherapy and/or external beam radiation results in a reduction in thyroid gland size. The impact on thyroid gland function remains unknown.
AB - We aimed to evaluate changes in thyroid gland size during the treatment of malignancies outside the head and neck with chemotherapy and/or external beam radiation. We performed a retrospective review of records of adult patients treated at our institution with external beam radiation to the chest and/or chemotherapy with taxanes, alkylating agents, and/or a topoisomerase II inhibitor. Neck and chest computed tomography (CT) images were used to calculate thyroid gland volume before and after therapy, using Vitrea® software or the volumetric ellipsoid method. Thirty-seven patients were included. After treatment, there was a significant reduction in thyroid gland volume of 14.0% (P < 0.01) using Vitrea and 17.1% (P < 0.05) using the volumetric ellipsoid method. Exposure to radiation or chemotherapy was not found to be associated with the degree of thyroid gland reduction, nor was the number of days between CT scans or the stage of the malignancy being treated. Finally, the degree of thyroid gland size reduction did not predict mortality. Our results showed that the treatment of malignancies outside the head and neck with chemotherapy and/or external beam radiation results in a reduction in thyroid gland size. The impact on thyroid gland function remains unknown.
KW - Chemoradiation
KW - radiosensitive
KW - secondary malignancy
KW - thyroid gland
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U2 - 10.1080/08998280.2020.1786227
DO - 10.1080/08998280.2020.1786227
M3 - Article
C2 - 33100524
AN - SCOPUS:85088480620
SN - 0899-8280
SP - 541
EP - 545
JO - Baylor University Medical Center Proceedings
JF - Baylor University Medical Center Proceedings
ER -