Effect of chronic pentobarbital treatment on the sleep patterns of squirrel monkeys

P. M. Adams, E. S. Barratt

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

Following a 30-day baseline, 60 days of sodium pentobarbital treatment (5 mg/kg) were given to squirrel monkeys 2 h prior to the start of a 12-h recording of EEG and EOG. Following the drugtreatment phase, an additional 30-day period was used to determine the rate of recovery. Repeated pentobarbital treatment significantly reduced awake time and slow wave sleep while it elevated the time spent in drowsy and light sleep. The recovery phase indicated a brief recovery of rapid eye movement sleep while the other stages failed to return to baseline levels. The cyclical nature of the changes observed with chronic pentobarbital suggest the importance of circadian fluctuations in the study of chronic drug treatment and the sleep-wakefulness process.

Original languageEnglish (US)
Pages (from-to)205-207
Number of pages3
JournalPsychopharmacology
Volume48
Issue number2
DOIs
StatePublished - Jan 1 1976

Keywords

  • Barbiturate
  • Sleep
  • Squirrel monkey

ASJC Scopus subject areas

  • Pharmacology

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