Effect of circadian phase on context and cued fear conditioning in C57BL/6J mice

Verónica S. Valentinuzzi, Daniel E. Kolker, Martha Hotz Vitaterna, Elenice A M Ferrari, Joseph S. Takahashi, Fred W. Turek

Research output: Contribution to journalArticle

40 Scopus citations


We examined context-dependent and tone-cued fear conditioning during the activity and rest periods of C57BL/6J mice. Wheel-running activity was measured continuously as a marker of circadian phase. To control the effects of light on the response, the animals were kept in a skeleton photoperiod (two 15-min light pulses per day, indicating the beginning and the end of the day). Half the animals were trained and tested for context-dependent fear conditioning 2 h after the morning light pulse; the other half were trained and tested 2 h after the evening light pulse. Animals were tested every 24 h for 5 days to analyze the conditioned response and the rate of extinction. They were then trained for tone-cued fear conditioning at the same time and tested for 5 consecutive days. A significant difference between the morning and the evening groups was observed in the conditioning level and extinction rate of context-dependent fear conditioning, but not in tone-cued fear conditioning. These results suggest a modulating effect of the biological clock on the context fear-conditioning pathway.

Original languageEnglish (US)
Pages (from-to)133-142
Number of pages10
JournalAnimal Learning and Behavior
Issue number2
StatePublished - Jan 1 2001


ASJC Scopus subject areas

  • Neuropsychology and Physiological Psychology
  • Experimental and Cognitive Psychology
  • Animal Science and Zoology
  • Psychology(all)
  • Behavioral Neuroscience

Cite this

Valentinuzzi, V. S., Kolker, D. E., Vitaterna, M. H., Ferrari, E. A. M., Takahashi, J. S., & Turek, F. W. (2001). Effect of circadian phase on context and cued fear conditioning in C57BL/6J mice. Animal Learning and Behavior, 29(2), 133-142. https://doi.org/10.3758/BF03192822