Effect of coexcipients on drug release and floating property of nifedipine hollow microspheres: A novel castro retentive drug delivery system

Kumaresh S. Soppimath, Tejraj M. Aminabhavi, Sunil A. Agnihotri, Nadagouda N. Mallikarjuna, Padmakar V. Kulkarni

Research output: Contribution to journalArticle

13 Scopus citations

Abstract

A gastro retentive drug-delivery system for nifedipine was developed by incorporating the drug in cellulose acetate hollow microspheres capable of floating on the gastric and intestinal fluid. The microspheres were prepared by solvent diffusion-evaporation technique in the presence of coexcipients like polyethylene glycol, dibutyl phthalate, and poly(e-caprolactone) using ethyl acetate as a dispersing solvent. Size of the microparticles depends upon the type and concentration of the excipient used. Microparticles exhibited floating properties on the simulated-gastric fluid for <12 h. Their percentage buoyancy followed the rank order of: blank (no coexcipients) > dibutyl phthalate > polyethylene glycol > poly(e-caprolactone) after 15 h of floating. Release of nifedepine was enhanced by the addition of coexcipients. The drug release followed non-Fickian transport in almost all formulations.

Original languageEnglish (US)
Pages (from-to)486-494
Number of pages9
JournalJournal of Applied Polymer Science
Volume100
Issue number1
DOIs
StatePublished - Apr 5 2006

Keywords

  • Drug-delivery systems
  • Excipients
  • Floating hollow microspheres
  • Nifedipine
  • Non-fickian transport

ASJC Scopus subject areas

  • Chemistry(all)
  • Surfaces, Coatings and Films
  • Polymers and Plastics
  • Materials Chemistry

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