Effect of coexcipients on drug release and floating property of nifedipine hollow microspheres: A novel castro retentive drug delivery system

Kumaresh S. Soppimath, Tejraj M. Aminabhavi, Sunil A. Agnihotri, Nadagouda N. Mallikarjuna, Padmakar V. Kulkarni

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

A gastro retentive drug-delivery system for nifedipine was developed by incorporating the drug in cellulose acetate hollow microspheres capable of floating on the gastric and intestinal fluid. The microspheres were prepared by solvent diffusion-evaporation technique in the presence of coexcipients like polyethylene glycol, dibutyl phthalate, and poly(e-caprolactone) using ethyl acetate as a dispersing solvent. Size of the microparticles depends upon the type and concentration of the excipient used. Microparticles exhibited floating properties on the simulated-gastric fluid for <12 h. Their percentage buoyancy followed the rank order of: blank (no coexcipients) > dibutyl phthalate > polyethylene glycol > poly(e-caprolactone) after 15 h of floating. Release of nifedepine was enhanced by the addition of coexcipients. The drug release followed non-Fickian transport in almost all formulations.

Original languageEnglish (US)
Pages (from-to)486-494
Number of pages9
JournalJournal of Applied Polymer Science
Volume100
Issue number1
DOIs
StatePublished - Apr 5 2006

Fingerprint

Dibutyl Phthalate
Nifedipine
Microspheres
Polyethylene glycols
Fluids
Excipients
Pharmaceutical Preparations
Cellulose
Evaporation
Drug Delivery Systems
caprolactone
acetylcellulose
ethyl acetate

Keywords

  • Drug-delivery systems
  • Excipients
  • Floating hollow microspheres
  • Nifedipine
  • Non-fickian transport

ASJC Scopus subject areas

  • Polymers and Plastics

Cite this

Effect of coexcipients on drug release and floating property of nifedipine hollow microspheres : A novel castro retentive drug delivery system. / Soppimath, Kumaresh S.; Aminabhavi, Tejraj M.; Agnihotri, Sunil A.; Mallikarjuna, Nadagouda N.; Kulkarni, Padmakar V.

In: Journal of Applied Polymer Science, Vol. 100, No. 1, 05.04.2006, p. 486-494.

Research output: Contribution to journalArticle

Soppimath, Kumaresh S. ; Aminabhavi, Tejraj M. ; Agnihotri, Sunil A. ; Mallikarjuna, Nadagouda N. ; Kulkarni, Padmakar V. / Effect of coexcipients on drug release and floating property of nifedipine hollow microspheres : A novel castro retentive drug delivery system. In: Journal of Applied Polymer Science. 2006 ; Vol. 100, No. 1. pp. 486-494.
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