Effect of cytokine-induced migration of Langerhans cells on corneal allograft survival

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Abstract

The unique paucity of Ia+ Langerhans cells (LCs) in the central cornea contributes to the immunological privilege of corneal allografts. A variety of stimuli can induce the centripetal migration of peripheral LCs. At least one of these stimuli (i.e. latex bead instillation) induces interleukin-1 (IL-1) secretion by corneal cells which acts as a potent chemoattractant for LCs. Within 30 minutes of intracorneal injection of IL-1, centripetal migration of LCs can be detected. The presence of donor-derived LCs in corneal allografts doubles the incidence of rejection of fully allogeneic corneal allografts as well as MHC matched, multiple minor H mismatched corneal allografts. Although the presence of donor-specific LCs greatly jeopardises corneal allograft survival, migration of host-derived LCs into corneal allografts does not appear to increase the risk of rejection.

Original languageEnglish (US)
Pages (from-to)215-218
Number of pages4
JournalEye
Volume9
Issue number2
Publication statusPublished - 1995

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Keywords

  • Corneal allograft
  • Cytokine
  • Keratoplasty
  • Langerhans cells

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems

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