Effect of deficient muscular glycogenolysis on extramuscular fuel production in exercise

J. Vissing, S. F. Lewis, H. Galbo, R. G. Haller

Research output: Contribution to journalArticle

55 Citations (Scopus)

Abstract

Hormonal, metabolic, and cardiovascular responses to 21 min of cycling in three saline- or glucose-infused men with McArdle's disease were compared with those of matched controls to elucidate whether mobilization of extramuscular fuel is enhanced to compensate for the lack of intramuscular glycogenolysis in patients with McArdle's disease. During exercise, all saline-infused patients compared with controls working at both the same absolute and at similar relative work rates had higher glucose production (31 ± 7 vs. 19 ± 5 and 26 ± 4 μmol · min-1 · kg-1) and utilization (34 ± 8 vs. 22 ± 2 and 28 ± 4 μmol · min-1 · kg-1); higher plasma glycerol (155 ± 19 vs. 75 ± 20 and 90 ± 22 μmol/l), free fatty acids (487 ± 175 vs. 295 ± 47 and 202 ± 52 μmol/l), growth hormone (7.7 ± 2.8 vs. 2.6 ± 1.1 and 3.6 ± 3.4 mU/l), and cortisol (530 ± 168 vs. 268 ± 8 and 367 ± 80 nmol/l), greater decrease in insulin (Δ57 ± 4 vs. Δ11 ± 8 and Δ11 ± 23 pmol/l), and similar glucose concentrations. Furthermore, norepinephrine, epinephrine, and adrenocorticotropic hormone levels were higher and heart rate and cardiac output were higher during exercise in all patients than in controls at the same absolute work rate. Glucose infusion induced hyperglycemia and hyperinsulinemia in patients and inhibited the exercise-induced increases in glucose production, glycerol, free fatty acids, catecholamines, growth hormone, cortisol, and heart rate. In conclusion, feedback from metabolism in contracting muscle enhances hormonal responses and extramuscular substrate mobilization during exercise in McArdle's disease.

Original languageEnglish (US)
Pages (from-to)1773-1779
Number of pages7
JournalJournal of Applied Physiology
Volume72
Issue number5
StatePublished - 1992

Fingerprint

Glycogenolysis
Glycogen Storage Disease Type V
Exercise
Glucose
Nonesterified Fatty Acids
Glycerol
Growth Hormone
Hydrocortisone
Heart Rate
High Cardiac Output
Hyperinsulinism
Hyperglycemia
Adrenocorticotropic Hormone
Epinephrine
Catecholamines
Norepinephrine
Insulin
Muscles

Keywords

  • adrenocorticotropic hormone
  • catecholamines
  • cycle exercise
  • glucose homeostasis
  • growth hormone
  • hepatic glucose production
  • insulin
  • McArdle's disease

ASJC Scopus subject areas

  • Endocrinology
  • Physiology
  • Orthopedics and Sports Medicine
  • Physical Therapy, Sports Therapy and Rehabilitation

Cite this

Effect of deficient muscular glycogenolysis on extramuscular fuel production in exercise. / Vissing, J.; Lewis, S. F.; Galbo, H.; Haller, R. G.

In: Journal of Applied Physiology, Vol. 72, No. 5, 1992, p. 1773-1779.

Research output: Contribution to journalArticle

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