Effect of dialysis on all trans retinoic acid levels in a child with acute promyelocytic leukemia and renal failure

Madhvi Rajpurkar, Patricia Alcasabas, Indulekha Warrier, Rudolph P. Valentini, Nancy Fassinger, Daniel A C Frattarelli, Yaddanapudi Ravindranath

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

All trans retinoic acid (ATRA) combined with chemotherapy has become the mainstay of treatment for patients with acute promyelocyte leukemia (APL). Renal dysfunction (RD) is commonly seen in patients with APL. We describe a patient with APL and multi-organ failure, who was on chronic veno-venous hemofiltration followed by hemodialysis (HD) and later peritoneal dialysis (PD), who received ATRA. ATRA levels were assessed as the body clearance of ATRA in children on HD and/or PD was unknown. Neither HD nor PD significantly affected ATRA levels, suggesting that dose modifications of ATRA may not be necessary for children with these forms of renal replacement therapy.

Original languageEnglish (US)
Pages (from-to)994-996
Number of pages3
JournalPediatric Blood and Cancer
Volume49
Issue number7
DOIs
StatePublished - Dec 2007

Fingerprint

Acute Promyelocytic Leukemia
Tretinoin
Renal Insufficiency
Dialysis
Granulocyte Precursor Cells
Peritoneal Dialysis
Renal Dialysis
Leukemia
Hemofiltration
Renal Replacement Therapy
Kidney
Drug Therapy

Keywords

  • All trans retinoic acid
  • Promyelocyte leukemia
  • Renal failure

ASJC Scopus subject areas

  • Cancer Research
  • Pediatrics, Perinatology, and Child Health
  • Hematology

Cite this

Rajpurkar, M., Alcasabas, P., Warrier, I., Valentini, R. P., Fassinger, N., Frattarelli, D. A. C., & Ravindranath, Y. (2007). Effect of dialysis on all trans retinoic acid levels in a child with acute promyelocytic leukemia and renal failure. Pediatric Blood and Cancer, 49(7), 994-996. https://doi.org/10.1002/pbc.20844

Effect of dialysis on all trans retinoic acid levels in a child with acute promyelocytic leukemia and renal failure. / Rajpurkar, Madhvi; Alcasabas, Patricia; Warrier, Indulekha; Valentini, Rudolph P.; Fassinger, Nancy; Frattarelli, Daniel A C; Ravindranath, Yaddanapudi.

In: Pediatric Blood and Cancer, Vol. 49, No. 7, 12.2007, p. 994-996.

Research output: Contribution to journalArticle

Rajpurkar, M, Alcasabas, P, Warrier, I, Valentini, RP, Fassinger, N, Frattarelli, DAC & Ravindranath, Y 2007, 'Effect of dialysis on all trans retinoic acid levels in a child with acute promyelocytic leukemia and renal failure', Pediatric Blood and Cancer, vol. 49, no. 7, pp. 994-996. https://doi.org/10.1002/pbc.20844
Rajpurkar, Madhvi ; Alcasabas, Patricia ; Warrier, Indulekha ; Valentini, Rudolph P. ; Fassinger, Nancy ; Frattarelli, Daniel A C ; Ravindranath, Yaddanapudi. / Effect of dialysis on all trans retinoic acid levels in a child with acute promyelocytic leukemia and renal failure. In: Pediatric Blood and Cancer. 2007 ; Vol. 49, No. 7. pp. 994-996.
@article{2fc17d31bbdf464d80e3577fe28329d7,
title = "Effect of dialysis on all trans retinoic acid levels in a child with acute promyelocytic leukemia and renal failure",
abstract = "All trans retinoic acid (ATRA) combined with chemotherapy has become the mainstay of treatment for patients with acute promyelocyte leukemia (APL). Renal dysfunction (RD) is commonly seen in patients with APL. We describe a patient with APL and multi-organ failure, who was on chronic veno-venous hemofiltration followed by hemodialysis (HD) and later peritoneal dialysis (PD), who received ATRA. ATRA levels were assessed as the body clearance of ATRA in children on HD and/or PD was unknown. Neither HD nor PD significantly affected ATRA levels, suggesting that dose modifications of ATRA may not be necessary for children with these forms of renal replacement therapy.",
keywords = "All trans retinoic acid, Promyelocyte leukemia, Renal failure",
author = "Madhvi Rajpurkar and Patricia Alcasabas and Indulekha Warrier and Valentini, {Rudolph P.} and Nancy Fassinger and Frattarelli, {Daniel A C} and Yaddanapudi Ravindranath",
year = "2007",
month = "12",
doi = "10.1002/pbc.20844",
language = "English (US)",
volume = "49",
pages = "994--996",
journal = "Pediatric Blood and Cancer",
issn = "1545-5009",
publisher = "Wiley-Liss Inc.",
number = "7",

}

TY - JOUR

T1 - Effect of dialysis on all trans retinoic acid levels in a child with acute promyelocytic leukemia and renal failure

AU - Rajpurkar, Madhvi

AU - Alcasabas, Patricia

AU - Warrier, Indulekha

AU - Valentini, Rudolph P.

AU - Fassinger, Nancy

AU - Frattarelli, Daniel A C

AU - Ravindranath, Yaddanapudi

PY - 2007/12

Y1 - 2007/12

N2 - All trans retinoic acid (ATRA) combined with chemotherapy has become the mainstay of treatment for patients with acute promyelocyte leukemia (APL). Renal dysfunction (RD) is commonly seen in patients with APL. We describe a patient with APL and multi-organ failure, who was on chronic veno-venous hemofiltration followed by hemodialysis (HD) and later peritoneal dialysis (PD), who received ATRA. ATRA levels were assessed as the body clearance of ATRA in children on HD and/or PD was unknown. Neither HD nor PD significantly affected ATRA levels, suggesting that dose modifications of ATRA may not be necessary for children with these forms of renal replacement therapy.

AB - All trans retinoic acid (ATRA) combined with chemotherapy has become the mainstay of treatment for patients with acute promyelocyte leukemia (APL). Renal dysfunction (RD) is commonly seen in patients with APL. We describe a patient with APL and multi-organ failure, who was on chronic veno-venous hemofiltration followed by hemodialysis (HD) and later peritoneal dialysis (PD), who received ATRA. ATRA levels were assessed as the body clearance of ATRA in children on HD and/or PD was unknown. Neither HD nor PD significantly affected ATRA levels, suggesting that dose modifications of ATRA may not be necessary for children with these forms of renal replacement therapy.

KW - All trans retinoic acid

KW - Promyelocyte leukemia

KW - Renal failure

UR - http://www.scopus.com/inward/record.url?scp=35648994252&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=35648994252&partnerID=8YFLogxK

U2 - 10.1002/pbc.20844

DO - 10.1002/pbc.20844

M3 - Article

VL - 49

SP - 994

EP - 996

JO - Pediatric Blood and Cancer

JF - Pediatric Blood and Cancer

SN - 1545-5009

IS - 7

ER -