Effect of dialysis on all trans retinoic acid levels in a child with acute promyelocytic leukemia and renal failure

Madhvi Rajpurkar, Patricia Alcasabas, Indulekha Warrier, Rudolph P. Valentini, Nancy Fassinger, Daniel A C Frattarelli, Yaddanapudi Ravindranath

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

All trans retinoic acid (ATRA) combined with chemotherapy has become the mainstay of treatment for patients with acute promyelocyte leukemia (APL). Renal dysfunction (RD) is commonly seen in patients with APL. We describe a patient with APL and multi-organ failure, who was on chronic veno-venous hemofiltration followed by hemodialysis (HD) and later peritoneal dialysis (PD), who received ATRA. ATRA levels were assessed as the body clearance of ATRA in children on HD and/or PD was unknown. Neither HD nor PD significantly affected ATRA levels, suggesting that dose modifications of ATRA may not be necessary for children with these forms of renal replacement therapy.

Original languageEnglish (US)
Pages (from-to)994-996
Number of pages3
JournalPediatric Blood and Cancer
Volume49
Issue number7
DOIs
StatePublished - Dec 1 2007

Keywords

  • All trans retinoic acid
  • Promyelocyte leukemia
  • Renal failure

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Hematology
  • Oncology

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    Rajpurkar, M., Alcasabas, P., Warrier, I., Valentini, R. P., Fassinger, N., Frattarelli, D. A. C., & Ravindranath, Y. (2007). Effect of dialysis on all trans retinoic acid levels in a child with acute promyelocytic leukemia and renal failure. Pediatric Blood and Cancer, 49(7), 994-996. https://doi.org/10.1002/pbc.20844