Effect of diphosphonate on crystallization of calcium oxalate in vitro

C. Y C Pak, M. Ohata, K. Holt

Research output: Contribution to journalArticle

47 Citations (Scopus)

Abstract

Reliable techniques for the calculation of activity product (state of saturation), formation product (limit of metastability) and crystal growth of calcium oxalate were devised. The activity product at saturation was 2.53x10-9M2, and was independent of duration of incubation, solid to solution ratio, pH, calcium concentration or ionic strength. These techniques were utilized to assess the effect of disodium etidronate (disodium ethane 1 hydroxy 1, 1 diphosphonate; EHDP) on crystalization of calcium oxalate in an aqueous salt solution in vitro. EHDP increased the formation product of calcium oxalate, indicating an inhibition of nucleation of calcium oxalate. Further, it inhibited the crystal growth of calcium oxalate.

Original languageEnglish (US)
Pages (from-to)154-160
Number of pages7
JournalKidney International
Volume7
Issue number3
StatePublished - 1975

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Calcium Oxalate
Diphosphonates
Crystallization
Etidronic Acid
Ethane
Osmolar Concentration
Salts
In Vitro Techniques
Calcium

ASJC Scopus subject areas

  • Nephrology

Cite this

Effect of diphosphonate on crystallization of calcium oxalate in vitro. / Pak, C. Y C; Ohata, M.; Holt, K.

In: Kidney International, Vol. 7, No. 3, 1975, p. 154-160.

Research output: Contribution to journalArticle

Pak, C. Y C ; Ohata, M. ; Holt, K. / Effect of diphosphonate on crystallization of calcium oxalate in vitro. In: Kidney International. 1975 ; Vol. 7, No. 3. pp. 154-160.
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