Effect of diterpenoid alkaloids on cardiac sympathetic efferent and vagal afferent nerve activity

Hsi Chiao, S. William Pelletier, Haridutt K. Desai, Winona R. Rebagay, R. William Caldwell

Research output: Contribution to journalArticle

21 Scopus citations

Abstract

The diterpenoid alkaloid, lappaconitine, at a dose of 150 μg/kg (i.v.) increased cardiac vagal afferent nerve activity (16.2%) and reduced cardiac sympathetic efferent nerve activity (12.5%). A polar analog, N-deacetyllappaconitine, at this same dose, increased cardiac vagal afferent nerve activity (40%) and reduced cardiac sympathetic efferent nerve activity (23.5%). Both of these agents also reduced arterial blood pressure and heart rate. A larger dose of lappaconitine (300 μg/kg i.v.) produced the same changes in nerve activities and cardiac function as the lower dose. Two other structurally related agents, lycoctonine and aconine, failed to alter these variables in doses up to 300 μg/kg. These data suggest that certain diterpenoid alkaloids activate autonomic reflex receptors, including cardiac reflex receptors. The polar agent, N-deacetyllappaconitine, appears to be more effective on cardiac reflex receptors than the non-polar agent, lappaconitine. Such agents may be useful in the treatment of hypertension.

Original languageEnglish (US)
Pages (from-to)103-106
Number of pages4
JournalEuropean Journal of Pharmacology
Volume283
Issue number1-3
DOIs
StatePublished - Sep 5 1995

Keywords

  • Autonomic nerve
  • Blood pressure
  • Diterpenoid alkaloid
  • Heart rate

ASJC Scopus subject areas

  • Pharmacology

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