Effect of ductus ligation on cardiopulmonary function in premature baboons

Donald C. McCurnin, Bradley A. Yoder, Jacqueline Coalson, Peter Grubb, Jay Kerecman, John Kupferschmid, Chris Breuer, Theresa Siler-Khodr, Philip W. Shaul, Ronald Clyman

Research output: Contribution to journalArticlepeer-review

43 Scopus citations

Abstract

Rationale: The role of the patent ductus arteriosus in the development of chronic lung disease in surfactant-treated premature newborns remains unclear. Objective: To examine the effects of ductus ligation on cardiopulmonary function and lung histopathology in premature primates. Methods: Baboons were delivered at 125 d, (term = 185 d) treated with surfactant, and ventilated for 14 d. Serial echocardiograms and pulmonary function tests were performed. Animals were randomized to ligation (n = 12) or no ligation (controls, n = 13) on Day 6 of life. Necropsy was performed on Day 14. Results: Compared with nonligated control animals, ligated animals had lower pulmonary-to-systemic flow ratios, higher systemic blood pressures, and improved indices of right and left ventricular performance. The ligated animals tended to have better compliance and ventilation indices for the last 3 d of the study. There were no differences between the groups in proinflammatory tracheal cytokines (interleukin [IL] 6 and IL-8), static lung compliance, or lung histology. Conclusion: Although a persistent patent ductus arteriosus results in diminished cardiac function and increased ventilatory requirements at the end of the second week of life, ligation on Day 6 had no measurable effect on the histologic evolution of chronic lung injury in this 14-d baboon model.

Original languageEnglish (US)
Pages (from-to)1569-1574
Number of pages6
JournalAmerican journal of respiratory and critical care medicine
Volume172
Issue number12
DOIs
StatePublished - Dec 15 2005

Keywords

  • Bronchopulmonary dysplasia
  • Chronic lung disease
  • Patent ductus arteriosus
  • Premature newborn

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Critical Care and Intensive Care Medicine

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