Effect of educational attainment on survival in Alzheimer's disease

Myron F. Weiner, Richard C. Risser

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

To test the hypothesis that education may affect clinical course and survival in Alzheimer's disease (AD) patients we examined retrospectively a large AD database and obtained information from the National Death Index concerning these patients. AD patients with >11 years of education (high school complete) were compared with AD patients who had <11 years of education (high school incomplete) on measures of cognition and overall function. As compared with AD patients with high school incomplete, AD patients with high school complete presented at a significantly earlier average age (72.9 ±8.6 vs. 75.9 ±6.5 years; p<0.001 ), with less cognitive impairment as indicated by Mini-mental State scores (17.0 ±6.2 vs. 14.8 ±6.0; p<0.001 ), but no difference in global functioning as indicated by scores on the Blessed Dementia Rating Scale. Despite their higher cognitive scores at entry, AD patients with high school complete had essentially the same duration of illness and died at a slightly earlier age than those with high school incomplete. Survival analysis showed no effect of concomitant heart disease, hypertension, lung disease, diabetes, thyroid disease, head injury or Parkinson symptoms; nor was there an effect of the life style factors of cigarette smoking or alcohol use.

Original languageEnglish (US)
Pages (from-to)369-374
Number of pages6
JournalAlzheimer's Reports
Volume1
Issue number6
StatePublished - 1998

Fingerprint

Alzheimer Disease
Survival
Education
Thyroid Diseases
Survival Analysis
Craniocerebral Trauma
Cognition
Lung Diseases
Dementia
Life Style
Heart Diseases
Smoking
Alcohols
Databases
Hypertension

Keywords

  • Alzheimer's disease
  • Education survival

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology

Cite this

Weiner, M. F., & Risser, R. C. (1998). Effect of educational attainment on survival in Alzheimer's disease. Alzheimer's Reports, 1(6), 369-374.

Effect of educational attainment on survival in Alzheimer's disease. / Weiner, Myron F.; Risser, Richard C.

In: Alzheimer's Reports, Vol. 1, No. 6, 1998, p. 369-374.

Research output: Contribution to journalArticle

Weiner, MF & Risser, RC 1998, 'Effect of educational attainment on survival in Alzheimer's disease', Alzheimer's Reports, vol. 1, no. 6, pp. 369-374.
Weiner, Myron F. ; Risser, Richard C. / Effect of educational attainment on survival in Alzheimer's disease. In: Alzheimer's Reports. 1998 ; Vol. 1, No. 6. pp. 369-374.
@article{205e8afe55144e179bca03d59e1ee7c0,
title = "Effect of educational attainment on survival in Alzheimer's disease",
abstract = "To test the hypothesis that education may affect clinical course and survival in Alzheimer's disease (AD) patients we examined retrospectively a large AD database and obtained information from the National Death Index concerning these patients. AD patients with >11 years of education (high school complete) were compared with AD patients who had <11 years of education (high school incomplete) on measures of cognition and overall function. As compared with AD patients with high school incomplete, AD patients with high school complete presented at a significantly earlier average age (72.9 ±8.6 vs. 75.9 ±6.5 years; p<0.001 ), with less cognitive impairment as indicated by Mini-mental State scores (17.0 ±6.2 vs. 14.8 ±6.0; p<0.001 ), but no difference in global functioning as indicated by scores on the Blessed Dementia Rating Scale. Despite their higher cognitive scores at entry, AD patients with high school complete had essentially the same duration of illness and died at a slightly earlier age than those with high school incomplete. Survival analysis showed no effect of concomitant heart disease, hypertension, lung disease, diabetes, thyroid disease, head injury or Parkinson symptoms; nor was there an effect of the life style factors of cigarette smoking or alcohol use.",
keywords = "Alzheimer's disease, Education survival",
author = "Weiner, {Myron F.} and Risser, {Richard C.}",
year = "1998",
language = "English (US)",
volume = "1",
pages = "369--374",
journal = "Alzheimer's Reports",
issn = "1461-6130",
publisher = "Cardiff University",
number = "6",

}

TY - JOUR

T1 - Effect of educational attainment on survival in Alzheimer's disease

AU - Weiner, Myron F.

AU - Risser, Richard C.

PY - 1998

Y1 - 1998

N2 - To test the hypothesis that education may affect clinical course and survival in Alzheimer's disease (AD) patients we examined retrospectively a large AD database and obtained information from the National Death Index concerning these patients. AD patients with >11 years of education (high school complete) were compared with AD patients who had <11 years of education (high school incomplete) on measures of cognition and overall function. As compared with AD patients with high school incomplete, AD patients with high school complete presented at a significantly earlier average age (72.9 ±8.6 vs. 75.9 ±6.5 years; p<0.001 ), with less cognitive impairment as indicated by Mini-mental State scores (17.0 ±6.2 vs. 14.8 ±6.0; p<0.001 ), but no difference in global functioning as indicated by scores on the Blessed Dementia Rating Scale. Despite their higher cognitive scores at entry, AD patients with high school complete had essentially the same duration of illness and died at a slightly earlier age than those with high school incomplete. Survival analysis showed no effect of concomitant heart disease, hypertension, lung disease, diabetes, thyroid disease, head injury or Parkinson symptoms; nor was there an effect of the life style factors of cigarette smoking or alcohol use.

AB - To test the hypothesis that education may affect clinical course and survival in Alzheimer's disease (AD) patients we examined retrospectively a large AD database and obtained information from the National Death Index concerning these patients. AD patients with >11 years of education (high school complete) were compared with AD patients who had <11 years of education (high school incomplete) on measures of cognition and overall function. As compared with AD patients with high school incomplete, AD patients with high school complete presented at a significantly earlier average age (72.9 ±8.6 vs. 75.9 ±6.5 years; p<0.001 ), with less cognitive impairment as indicated by Mini-mental State scores (17.0 ±6.2 vs. 14.8 ±6.0; p<0.001 ), but no difference in global functioning as indicated by scores on the Blessed Dementia Rating Scale. Despite their higher cognitive scores at entry, AD patients with high school complete had essentially the same duration of illness and died at a slightly earlier age than those with high school incomplete. Survival analysis showed no effect of concomitant heart disease, hypertension, lung disease, diabetes, thyroid disease, head injury or Parkinson symptoms; nor was there an effect of the life style factors of cigarette smoking or alcohol use.

KW - Alzheimer's disease

KW - Education survival

UR - http://www.scopus.com/inward/record.url?scp=33746676271&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33746676271&partnerID=8YFLogxK

M3 - Article

AN - SCOPUS:33746676271

VL - 1

SP - 369

EP - 374

JO - Alzheimer's Reports

JF - Alzheimer's Reports

SN - 1461-6130

IS - 6

ER -