Effect of estradiol-17β on blood flow to reproductive and nonreproductive tissues in pregnant ewes

Charles R. Rosenfeld, Frank H. Morriss, Frederick C. Battaglia, Edgar L. Makowski, Giacomo Meschia

Research output: Contribution to journalArticle

102 Citations (Scopus)

Abstract

The effect of estradiol-17β (1 μg per kilogram) on regional blood flow and cardiac output was studied by means of radionuclide-labeled microspheres in 6 nonpregnant and 13 pregnant ewes five to seven days after operation. Estradiol caused vasodilation in myometrium, endometrium, and placental cotyledons throughout pregnancy, but these responses were significantly less than the fifteenfold increase seen in the nonpregnant uterine tissues. Significant vasodilation also occurred in the ovaries, cervix, vagina, uterine tubes, mammary gland, skin, and adrenal glands of pregnant ewes. Cardiac output increased by 14 per cent. No significant change in uterine oxygen consumption was associated with the increase in blood flow to the pregnant uterus.

Original languageEnglish (US)
Pages (from-to)618-629
Number of pages12
JournalAmerican Journal of Obstetrics and Gynecology
Volume124
Issue number6
StatePublished - Mar 15 1976

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Vasodilation
Cardiac Output
Estradiol
Fallopian Tubes
Cotyledon
Myometrium
Regional Blood Flow
Vagina
Human Mammary Glands
Adrenal Glands
Endometrium
Microspheres
Cervix Uteri
Oxygen Consumption
Radioisotopes
Uterus
Ovary
Pregnancy
Skin

ASJC Scopus subject areas

  • Medicine(all)
  • Obstetrics and Gynecology

Cite this

Effect of estradiol-17β on blood flow to reproductive and nonreproductive tissues in pregnant ewes. / Rosenfeld, Charles R.; Morriss, Frank H.; Battaglia, Frederick C.; Makowski, Edgar L.; Meschia, Giacomo.

In: American Journal of Obstetrics and Gynecology, Vol. 124, No. 6, 15.03.1976, p. 618-629.

Research output: Contribution to journalArticle

Rosenfeld, Charles R. ; Morriss, Frank H. ; Battaglia, Frederick C. ; Makowski, Edgar L. ; Meschia, Giacomo. / Effect of estradiol-17β on blood flow to reproductive and nonreproductive tissues in pregnant ewes. In: American Journal of Obstetrics and Gynecology. 1976 ; Vol. 124, No. 6. pp. 618-629.
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