Effect of etodolac in patients with moderate renal impairment compared with normal subjects

D. Craig Brater, Shirley A. Anderson, Debbie Brown-Cartwright, Robert D. Toto, Andrew Chen, Ginette B. Jacob

Research output: Contribution to journalArticle

18 Scopus citations

Abstract

Twenty subjects (10 with normal renal function and 10 with moderate renal insufficiency) participated in an 8-day study to assess the effects of acute and chronic etodolac dosing on renal function. Subjects and patients were hospitalized and followed a controlled diet (150 mEq sodium, 60 to 80 mEq potassium) during the study. A 3-day drug-free period was followed by 4 days of etodolac, 200 mg b.i.d. Sodium balance and body weight remained unchanged in both groups. Modest reductions in renal function as measured by clearances of inulin and p-aminohippurate occurred acutely only in the patients with renal impairment. Chronic therapy resulted in no decrements in daily creatinine clearance. In an average effective anti-inflammatory dose, etodolac did not produce a sustained effect on renal function in either normal subjects or patients with moderate renal insufficiency.

Original languageEnglish (US)
Pages (from-to)674-679
Number of pages6
JournalClinical pharmacology and therapeutics
Volume38
Issue number6
DOIs
StatePublished - Dec 1985

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)

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