Effect of Extended-Release Niacin on Carotid Intima Media Thickness, Reactive Hyperemia, and Endothelial Progenitor Cell Mobilization

Insights from the Atherosclerosis Lesion Progression Intervention Using Niacin Extended Release in Saphenous Vein Grafts (ALPINE-SVG) Pilot Trial

Andres Guerra, Bavana Venkata Rangan, Ameka Coleman, Hao Xu, Anna Kotsia, Georgios Christopoulos, Alan Sosa, Howard Chao, Henry Han, Guthbudeen Abdurrahim, Michele Roesle, James A de Lemos, Darren K McGuire, Milton Packer, Subhash Banerjee, Emmanouil S Brilakis

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

BACKGROUND: Thirty-eight patients with intermediate (30%-60% diameter stenosis) saphenous vein graft lesions were randomized to extended-release niacin (ER-niacin) or placebo for 12 months. We sought to evaluate the impact of ER-niacin on carotid intima media thickness (CIMT), endothelial function, and endothelial progenitor cell (EPC) mobilization. METHODS: Carotid B-mode ultrasound was used to image the common and internal carotid arteries, at baseline and at 12 months after enrollment. Reactive hyperemia peripheral arterial tonometry, as assessed with EndoPAT 2000 (Itamar Medical, Inc) and EPC mobilization assessed with flow cytometry, were measured at enrollment, and at 1 and 12 months. RESULTS: The baseline clinical characteristics were similar in the two study groups. High-density lipoprotein cholesterol levels tended to increase more in the ER-niacin group (5.9 ± 8.7 mg/dL vs 1.4 ± 7.1 mg/dL; P≤.14). Between baseline and 12 months, right common carotid artery (0.96 ± 0.44 mm vs 0.70 ± 0.24 mm; P≤.04), and left common carotid artery (0.80 ± 0.30 mm vs 0.70 ± 0.20 mm; P≤.08) CIMT tended to decrease in the ER-niacin group, compared with no change in the placebo group. The change in logarithmic reactive hyperemia index between 1 month and 12 months was similar in patients receiving ER-niacin vs placebo (0.003 ± 0.12 vs -0.058 ± 0.12; P≤.39), whereas EPC mobilization increased in the ER-niacin group and decreased in the placebo group (8.65 ± 28.41 vs -5.87 ± 30.23 EPC colony forming units/mL of peripheral blood; P≤.02). CONCLUSIONS: ER-niacin did not have a significant impact on CIMT or endothelial function, but increased EPC mobilization.

Original languageEnglish (US)
Pages (from-to)555-560
Number of pages6
JournalJournal of Invasive Cardiology
Volume27
Issue number12
StatePublished - Dec 1 2015

Fingerprint

Carotid Intima-Media Thickness
Niacin
Hyperemia
Saphenous Vein
Atherosclerosis
Transplants
Common Carotid Artery
Placebos
Manometry
Internal Carotid Artery
Endothelial Progenitor Cells
HDL Cholesterol
Flow Cytometry
Pathologic Constriction
Stem Cells

Keywords

  • atherosclerosis
  • cardiac surgery
  • carotid artery disease
  • niacin
  • saphenous vein graft

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Radiology Nuclear Medicine and imaging

Cite this

@article{1015131c363d47629529dc642068e7f8,
title = "Effect of Extended-Release Niacin on Carotid Intima Media Thickness, Reactive Hyperemia, and Endothelial Progenitor Cell Mobilization: Insights from the Atherosclerosis Lesion Progression Intervention Using Niacin Extended Release in Saphenous Vein Grafts (ALPINE-SVG) Pilot Trial",
abstract = "BACKGROUND: Thirty-eight patients with intermediate (30{\%}-60{\%} diameter stenosis) saphenous vein graft lesions were randomized to extended-release niacin (ER-niacin) or placebo for 12 months. We sought to evaluate the impact of ER-niacin on carotid intima media thickness (CIMT), endothelial function, and endothelial progenitor cell (EPC) mobilization. METHODS: Carotid B-mode ultrasound was used to image the common and internal carotid arteries, at baseline and at 12 months after enrollment. Reactive hyperemia peripheral arterial tonometry, as assessed with EndoPAT 2000 (Itamar Medical, Inc) and EPC mobilization assessed with flow cytometry, were measured at enrollment, and at 1 and 12 months. RESULTS: The baseline clinical characteristics were similar in the two study groups. High-density lipoprotein cholesterol levels tended to increase more in the ER-niacin group (5.9 ± 8.7 mg/dL vs 1.4 ± 7.1 mg/dL; P≤.14). Between baseline and 12 months, right common carotid artery (0.96 ± 0.44 mm vs 0.70 ± 0.24 mm; P≤.04), and left common carotid artery (0.80 ± 0.30 mm vs 0.70 ± 0.20 mm; P≤.08) CIMT tended to decrease in the ER-niacin group, compared with no change in the placebo group. The change in logarithmic reactive hyperemia index between 1 month and 12 months was similar in patients receiving ER-niacin vs placebo (0.003 ± 0.12 vs -0.058 ± 0.12; P≤.39), whereas EPC mobilization increased in the ER-niacin group and decreased in the placebo group (8.65 ± 28.41 vs -5.87 ± 30.23 EPC colony forming units/mL of peripheral blood; P≤.02). CONCLUSIONS: ER-niacin did not have a significant impact on CIMT or endothelial function, but increased EPC mobilization.",
keywords = "atherosclerosis, cardiac surgery, carotid artery disease, niacin, saphenous vein graft",
author = "Andres Guerra and Rangan, {Bavana Venkata} and Ameka Coleman and Hao Xu and Anna Kotsia and Georgios Christopoulos and Alan Sosa and Howard Chao and Henry Han and Guthbudeen Abdurrahim and Michele Roesle and {de Lemos}, {James A} and McGuire, {Darren K} and Milton Packer and Subhash Banerjee and Brilakis, {Emmanouil S}",
year = "2015",
month = "12",
day = "1",
language = "English (US)",
volume = "27",
pages = "555--560",
journal = "Journal of Invasive Cardiology",
issn = "1042-3931",
publisher = "HMP Communications",
number = "12",

}

TY - JOUR

T1 - Effect of Extended-Release Niacin on Carotid Intima Media Thickness, Reactive Hyperemia, and Endothelial Progenitor Cell Mobilization

T2 - Insights from the Atherosclerosis Lesion Progression Intervention Using Niacin Extended Release in Saphenous Vein Grafts (ALPINE-SVG) Pilot Trial

AU - Guerra, Andres

AU - Rangan, Bavana Venkata

AU - Coleman, Ameka

AU - Xu, Hao

AU - Kotsia, Anna

AU - Christopoulos, Georgios

AU - Sosa, Alan

AU - Chao, Howard

AU - Han, Henry

AU - Abdurrahim, Guthbudeen

AU - Roesle, Michele

AU - de Lemos, James A

AU - McGuire, Darren K

AU - Packer, Milton

AU - Banerjee, Subhash

AU - Brilakis, Emmanouil S

PY - 2015/12/1

Y1 - 2015/12/1

N2 - BACKGROUND: Thirty-eight patients with intermediate (30%-60% diameter stenosis) saphenous vein graft lesions were randomized to extended-release niacin (ER-niacin) or placebo for 12 months. We sought to evaluate the impact of ER-niacin on carotid intima media thickness (CIMT), endothelial function, and endothelial progenitor cell (EPC) mobilization. METHODS: Carotid B-mode ultrasound was used to image the common and internal carotid arteries, at baseline and at 12 months after enrollment. Reactive hyperemia peripheral arterial tonometry, as assessed with EndoPAT 2000 (Itamar Medical, Inc) and EPC mobilization assessed with flow cytometry, were measured at enrollment, and at 1 and 12 months. RESULTS: The baseline clinical characteristics were similar in the two study groups. High-density lipoprotein cholesterol levels tended to increase more in the ER-niacin group (5.9 ± 8.7 mg/dL vs 1.4 ± 7.1 mg/dL; P≤.14). Between baseline and 12 months, right common carotid artery (0.96 ± 0.44 mm vs 0.70 ± 0.24 mm; P≤.04), and left common carotid artery (0.80 ± 0.30 mm vs 0.70 ± 0.20 mm; P≤.08) CIMT tended to decrease in the ER-niacin group, compared with no change in the placebo group. The change in logarithmic reactive hyperemia index between 1 month and 12 months was similar in patients receiving ER-niacin vs placebo (0.003 ± 0.12 vs -0.058 ± 0.12; P≤.39), whereas EPC mobilization increased in the ER-niacin group and decreased in the placebo group (8.65 ± 28.41 vs -5.87 ± 30.23 EPC colony forming units/mL of peripheral blood; P≤.02). CONCLUSIONS: ER-niacin did not have a significant impact on CIMT or endothelial function, but increased EPC mobilization.

AB - BACKGROUND: Thirty-eight patients with intermediate (30%-60% diameter stenosis) saphenous vein graft lesions were randomized to extended-release niacin (ER-niacin) or placebo for 12 months. We sought to evaluate the impact of ER-niacin on carotid intima media thickness (CIMT), endothelial function, and endothelial progenitor cell (EPC) mobilization. METHODS: Carotid B-mode ultrasound was used to image the common and internal carotid arteries, at baseline and at 12 months after enrollment. Reactive hyperemia peripheral arterial tonometry, as assessed with EndoPAT 2000 (Itamar Medical, Inc) and EPC mobilization assessed with flow cytometry, were measured at enrollment, and at 1 and 12 months. RESULTS: The baseline clinical characteristics were similar in the two study groups. High-density lipoprotein cholesterol levels tended to increase more in the ER-niacin group (5.9 ± 8.7 mg/dL vs 1.4 ± 7.1 mg/dL; P≤.14). Between baseline and 12 months, right common carotid artery (0.96 ± 0.44 mm vs 0.70 ± 0.24 mm; P≤.04), and left common carotid artery (0.80 ± 0.30 mm vs 0.70 ± 0.20 mm; P≤.08) CIMT tended to decrease in the ER-niacin group, compared with no change in the placebo group. The change in logarithmic reactive hyperemia index between 1 month and 12 months was similar in patients receiving ER-niacin vs placebo (0.003 ± 0.12 vs -0.058 ± 0.12; P≤.39), whereas EPC mobilization increased in the ER-niacin group and decreased in the placebo group (8.65 ± 28.41 vs -5.87 ± 30.23 EPC colony forming units/mL of peripheral blood; P≤.02). CONCLUSIONS: ER-niacin did not have a significant impact on CIMT or endothelial function, but increased EPC mobilization.

KW - atherosclerosis

KW - cardiac surgery

KW - carotid artery disease

KW - niacin

KW - saphenous vein graft

UR - http://www.scopus.com/inward/record.url?scp=84948745278&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84948745278&partnerID=8YFLogxK

M3 - Article

VL - 27

SP - 555

EP - 560

JO - Journal of Invasive Cardiology

JF - Journal of Invasive Cardiology

SN - 1042-3931

IS - 12

ER -