Effect of gastric inhibitory polypeptide on plasma levels of chylomicron triglycerides in dogs

T. Wasada, K. McCorkle, V. Harris, K. Kawai, B. Howard, Roger H Unger

Research output: Contribution to journalArticle

121 Scopus citations

Abstract

To determine whether gastric inhibitory polypeptide (GIP) promotes the clearance of chylomicron triglycerides (TG) from the circulation in dogs, chyle collected from donor dogs via a thoracic duct fistula was infused at a rate of 2 ml/min i.v. into normal recipient dogs during an infusion of either porcine GIP (1 μg/kg per h) or saline as a control. In the GIP-infused dogs the rise in plasma TG was significantly below that of the control animals [mean peak of 36 ± 4 mg/dl vs. 82 ± 18 mg/dl (P <0.05)]. It is concluded that GIP exerts an effect upon the removal of chylomicron TG from the blood. The results suggest that GIP may play a physiologic role in the disposition of ingested fat.

Original languageEnglish (US)
Pages (from-to)1106-1107
Number of pages2
JournalUnknown Journal
Volume68
Issue number4
DOIs
StatePublished - 1981

ASJC Scopus subject areas

  • Medicine(all)

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