Effect of gastric inhibitory polypeptide on plasma levels of chylomicron triglycerides in dogs

T. Wasada, K. McCorkle, V. Harris, K. Kawai, B. Howard, Roger H Unger

Research output: Contribution to journalArticle

111 Citations (Scopus)

Abstract

To determine whether gastric inhibitory polypeptide (GIP) promotes the clearance of chylomicron triglycerides (TG) from the circulation in dogs, chyle collected from donor dogs via a thoracic duct fistula was infused at a rate of 2 ml/min i.v. into normal recipient dogs during an infusion of either porcine GIP (1 μg/kg per h) or saline as a control. In the GIP-infused dogs the rise in plasma TG was significantly below that of the control animals [mean peak of 36 ± 4 mg/dl vs. 82 ± 18 mg/dl (P <0.05)]. It is concluded that GIP exerts an effect upon the removal of chylomicron TG from the blood. The results suggest that GIP may play a physiologic role in the disposition of ingested fat.

Original languageEnglish (US)
Pages (from-to)1106-1107
Number of pages2
JournalJournal of Clinical Investigation
Volume68
Issue number4
StatePublished - 1981

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Gastric Inhibitory Polypeptide
Chylomicrons
Triglycerides
Dogs
Chyle
Thoracic Duct
Fistula
Swine
Fats

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Effect of gastric inhibitory polypeptide on plasma levels of chylomicron triglycerides in dogs. / Wasada, T.; McCorkle, K.; Harris, V.; Kawai, K.; Howard, B.; Unger, Roger H.

In: Journal of Clinical Investigation, Vol. 68, No. 4, 1981, p. 1106-1107.

Research output: Contribution to journalArticle

Wasada, T, McCorkle, K, Harris, V, Kawai, K, Howard, B & Unger, RH 1981, 'Effect of gastric inhibitory polypeptide on plasma levels of chylomicron triglycerides in dogs', Journal of Clinical Investigation, vol. 68, no. 4, pp. 1106-1107.
Wasada, T. ; McCorkle, K. ; Harris, V. ; Kawai, K. ; Howard, B. ; Unger, Roger H. / Effect of gastric inhibitory polypeptide on plasma levels of chylomicron triglycerides in dogs. In: Journal of Clinical Investigation. 1981 ; Vol. 68, No. 4. pp. 1106-1107.
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