Abstract
To determine whether gastric inhibitory polypeptide (GIP) promotes the clearance of chylomicron triglycerides (TG) from the circulation in dogs, chyle collected from donor dogs via a thoracic duct fistula was infused at a rate of 2 ml/min i.v. into normal recipient dogs during an infusion of either porcine GIP (1 μg/kg per h) or saline as a control. In the GIP-infused dogs the rise in plasma TG was significantly below that of the control animals [mean peak of 36 ± 4 mg/dl vs. 82 ± 18 mg/dl (P <0.05)]. It is concluded that GIP exerts an effect upon the removal of chylomicron TG from the blood. The results suggest that GIP may play a physiologic role in the disposition of ingested fat.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1106-1107 |
| Number of pages | 2 |
| Journal | Unknown Journal |
| Volume | 68 |
| Issue number | 4 |
| DOIs | |
| State | Published - 1981 |
ASJC Scopus subject areas
- General Medicine