Effect of glipizide on the surgically altered pancreas

John D. Barr, Eileen S. Parish, David A. Krusch, A. Hollis Farris, Arthur H. Freedlender, Donald L. Kaiser, John B. Hanks

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Abstract

Surgical alterations of the pancreas affect peripheral glucose, insulin, and glucagon levels with accompanying changes in carbohydrate metabolism. The sulfonylurea glipizide has been used to treat insulin-deficient states; however, its mechanism is not completely known. We hypothesized that glipizide would correct postoperative changes in glucose handling in a way that would allow more complete understanding of the drug's action. Two surgical groups (Group 1: 80 percent proximal pancreatectomy; Group 2: proximal pancreatectomy plus splenocaval diversion) were compared with a healthy control group (Group 3). We have concluded that glipizide may have affected basal insulin sensitivity in the control group and Group 2 animals without affecting insulin secretion in response to oral or intravenous glucose stimulation. Glipizide does not correct the alterations in glucose handling or insulin secretion after reduction in beta-cell mass.

Original languageEnglish (US)
Pages (from-to)103-108
Number of pages6
JournalThe American Journal of Surgery
Volume157
Issue number1
DOIs
Publication statusPublished - 1989

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ASJC Scopus subject areas

  • Surgery

Cite this

Barr, J. D., Parish, E. S., Krusch, D. A., Farris, A. H., Freedlender, A. H., Kaiser, D. L., & Hanks, J. B. (1989). Effect of glipizide on the surgically altered pancreas. The American Journal of Surgery, 157(1), 103-108. https://doi.org/10.1016/0002-9610(89)90428-5