Effect of glipizide on the surgically altered pancreas

John D. Barr; Eileen S. Parish; David A. Krusch; A. Hollis Farris; Arthur H. Freedlender; Donald L. Kaiser; John B. Hanks

doi:10.1016/0002-9610(89)90428-5

Effect of glipizide on the surgically altered pancreas

John D. Barr, Eileen S. Parish, David A. Krusch, A. Hollis Farris, Arthur H. Freedlender, Donald L. Kaiser, John B. Hanks

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2 Scopus citations

Abstract

Surgical alterations of the pancreas affect peripheral glucose, insulin, and glucagon levels with accompanying changes in carbohydrate metabolism. The sulfonylurea glipizide has been used to treat insulin-deficient states; however, its mechanism is not completely known. We hypothesized that glipizide would correct postoperative changes in glucose handling in a way that would allow more complete understanding of the drug's action. Two surgical groups (Group 1: 80 percent proximal pancreatectomy; Group 2: proximal pancreatectomy plus splenocaval diversion) were compared with a healthy control group (Group 3). We have concluded that glipizide may have affected basal insulin sensitivity in the control group and Group 2 animals without affecting insulin secretion in response to oral or intravenous glucose stimulation. Glipizide does not correct the alterations in glucose handling or insulin secretion after reduction in beta-cell mass.

Original language	English (US)
Pages (from-to)	103-108
Number of pages	6
Journal	The American Journal of Surgery
Volume	157
Issue number	1
DOIs	https://doi.org/10.1016/0002-9610(89)90428-5
State	Published - Jan 1989

ASJC Scopus subject areas

Surgery

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10.1016/0002-9610(89)90428-5

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title = "Effect of glipizide on the surgically altered pancreas",

abstract = "Surgical alterations of the pancreas affect peripheral glucose, insulin, and glucagon levels with accompanying changes in carbohydrate metabolism. The sulfonylurea glipizide has been used to treat insulin-deficient states; however, its mechanism is not completely known. We hypothesized that glipizide would correct postoperative changes in glucose handling in a way that would allow more complete understanding of the drug's action. Two surgical groups (Group 1: 80 percent proximal pancreatectomy; Group 2: proximal pancreatectomy plus splenocaval diversion) were compared with a healthy control group (Group 3). We have concluded that glipizide may have affected basal insulin sensitivity in the control group and Group 2 animals without affecting insulin secretion in response to oral or intravenous glucose stimulation. Glipizide does not correct the alterations in glucose handling or insulin secretion after reduction in beta-cell mass.",

author = "Barr, {John D.} and Parish, {Eileen S.} and Krusch, {David A.} and Farris, {A. Hollis} and Freedlender, {Arthur H.} and Kaiser, {Donald L.} and Hanks, {John B.}",

note = "Funding Information: From the Departments of Surgery and Medicine, University of Virginia Medical Center, Charlottesville, Virginia. Supported in part by National Institutes of Health Grant 1R23 AM35222-OIAI and R29 DK39595-01 (JBH), Bethesda, Maryland and by a grant from Pfiir-Rtig (87-R-OO3A) (EP and JBH), New York, New York. Data handling and analpis made possible by National Institutes of Health Grant MOlRR UO87, awarded to the University of Virginia General Clinical Research Center (DLK). Requests for reprints should be addressed to John B. Hanks, MD, Box 181, University of Virginia Malical Center, Charlottesville, Virginia 22908. Presented at the 29th Annual Meeting of the Society for Surgery of the Alimentary Tract, New Orleans, Louisiana, May 17-18.1988.",

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AU - Kaiser, Donald L.

AU - Hanks, John B.

N1 - Funding Information: From the Departments of Surgery and Medicine, University of Virginia Medical Center, Charlottesville, Virginia. Supported in part by National Institutes of Health Grant 1R23 AM35222-OIAI and R29 DK39595-01 (JBH), Bethesda, Maryland and by a grant from Pfiir-Rtig (87-R-OO3A) (EP and JBH), New York, New York. Data handling and analpis made possible by National Institutes of Health Grant MOlRR UO87, awarded to the University of Virginia General Clinical Research Center (DLK). Requests for reprints should be addressed to John B. Hanks, MD, Box 181, University of Virginia Malical Center, Charlottesville, Virginia 22908. Presented at the 29th Annual Meeting of the Society for Surgery of the Alimentary Tract, New Orleans, Louisiana, May 17-18.1988.

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Effect of glipizide on the surgically altered pancreas

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