Effect of hepatic irradiation on the toxicity and pharmacokinetics of adriamycin in children

John S. Holcenberg, Larry E. Kun, Barbara J. Ring, William E. Evans

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

The effect of hepatic irradiation on adriamycin toxicity and pharmacokinetics was studied in 10 children who received adriamycin with concurrent abdominal irradiation for Wilms' tumor. Hepatic irradiation to 2400-2700 rad at 100-150 rad per fraction did not alter the clinical toxicity or plasma pharmacokinetics of adriamycin.

Original languageEnglish (US)
Pages (from-to)953-956
Number of pages4
JournalInternational Journal of Radiation Oncology, Biology, Physics
Volume7
Issue number7
DOIs
StatePublished - Jan 1 1981

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toxicity
Doxorubicin
Pharmacokinetics
irradiation
Liver
Wilms Tumor
tumors

Keywords

  • Adriamycin
  • Hepatic irradiation
  • Pharmacokinetics
  • Toxicity
  • Wilms' tumor

ASJC Scopus subject areas

  • Radiation
  • Oncology
  • Radiology Nuclear Medicine and imaging
  • Cancer Research

Cite this

Effect of hepatic irradiation on the toxicity and pharmacokinetics of adriamycin in children. / Holcenberg, John S.; Kun, Larry E.; Ring, Barbara J.; Evans, William E.

In: International Journal of Radiation Oncology, Biology, Physics, Vol. 7, No. 7, 01.01.1981, p. 953-956.

Research output: Contribution to journalArticle

Holcenberg, John S. ; Kun, Larry E. ; Ring, Barbara J. ; Evans, William E. / Effect of hepatic irradiation on the toxicity and pharmacokinetics of adriamycin in children. In: International Journal of Radiation Oncology, Biology, Physics. 1981 ; Vol. 7, No. 7. pp. 953-956.
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