Effect of High and Low Calcium Diets on Stone Forming Risk During Liberal Oxalate Intake

Edward D. Matsumoto, Howard J. Heller, Beverley A Huet, Linda J. Brinkley, Charles Y Pak, Margaret S Pearle

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Purpose: Recent studies suggest that a high calcium diet protects against calcium oxalate stone formation. We compared the effect of high and low calcium diets on urinary saturation of calcium oxalate during liberal oxalate intake. Materials and Methods: A total of 10 healthy subjects (5 male, 5 female) participated in a 2-phase, randomized, crossover study comparing high (1,000 mg daily) and low (400 mg daily) calcium intake on a liberal oxalate diet (200 mg daily). During each phase subjects adhered to an instructed diet for 3 days followed by a controlled, metabolic diet for 4 days. Blood and 24-hour urine specimens collected on the last 2 days of each phase were analyzed for serum biochemistry studies and stone risk factors, respectively. Results: Urinary calcium was higher (mean ± SD 171 ± 64 vs 124 ± 49 mg daily, p = 0.002) and oxalate was lower (25 ± 4.8 vs 27 ± 4 mg daily, p = 0.02) on the high vs low calcium diet. Overall, the urinary relative saturation ratio of calcium oxalate was higher on the high compared with the low calcium diet (3.3 vs 2.5, p <0.0001) even after adjusting for confounding variables. Conclusions: In normal subjects urinary saturation of calcium oxalate was higher on a high calcium diet than a low calcium diet during liberal oxalate intake because the decrease in urinary oxalate did not overcome the effect of increased calcium. A high calcium diet during liberal oxalate intake may pose an increased risk of calcium oxalate stone formation.

Original languageEnglish (US)
Pages (from-to)132-136
Number of pages5
JournalJournal of Urology
Volume176
Issue number1
DOIs
StatePublished - Jul 2006

Fingerprint

Oxalates
Diet
Calcium
Calcium Oxalate
Confounding Factors (Epidemiology)
Biochemistry
Cross-Over Studies
Healthy Volunteers
Urine

Keywords

  • calcium
  • diet
  • kidney calculi
  • oxalates

ASJC Scopus subject areas

  • Urology

Cite this

Effect of High and Low Calcium Diets on Stone Forming Risk During Liberal Oxalate Intake. / Matsumoto, Edward D.; Heller, Howard J.; Huet, Beverley A; Brinkley, Linda J.; Pak, Charles Y; Pearle, Margaret S.

In: Journal of Urology, Vol. 176, No. 1, 07.2006, p. 132-136.

Research output: Contribution to journalArticle

Matsumoto, Edward D. ; Heller, Howard J. ; Huet, Beverley A ; Brinkley, Linda J. ; Pak, Charles Y ; Pearle, Margaret S. / Effect of High and Low Calcium Diets on Stone Forming Risk During Liberal Oxalate Intake. In: Journal of Urology. 2006 ; Vol. 176, No. 1. pp. 132-136.
@article{13fa020958ff4433a5cbde0a1babc527,
title = "Effect of High and Low Calcium Diets on Stone Forming Risk During Liberal Oxalate Intake",
abstract = "Purpose: Recent studies suggest that a high calcium diet protects against calcium oxalate stone formation. We compared the effect of high and low calcium diets on urinary saturation of calcium oxalate during liberal oxalate intake. Materials and Methods: A total of 10 healthy subjects (5 male, 5 female) participated in a 2-phase, randomized, crossover study comparing high (1,000 mg daily) and low (400 mg daily) calcium intake on a liberal oxalate diet (200 mg daily). During each phase subjects adhered to an instructed diet for 3 days followed by a controlled, metabolic diet for 4 days. Blood and 24-hour urine specimens collected on the last 2 days of each phase were analyzed for serum biochemistry studies and stone risk factors, respectively. Results: Urinary calcium was higher (mean ± SD 171 ± 64 vs 124 ± 49 mg daily, p = 0.002) and oxalate was lower (25 ± 4.8 vs 27 ± 4 mg daily, p = 0.02) on the high vs low calcium diet. Overall, the urinary relative saturation ratio of calcium oxalate was higher on the high compared with the low calcium diet (3.3 vs 2.5, p <0.0001) even after adjusting for confounding variables. Conclusions: In normal subjects urinary saturation of calcium oxalate was higher on a high calcium diet than a low calcium diet during liberal oxalate intake because the decrease in urinary oxalate did not overcome the effect of increased calcium. A high calcium diet during liberal oxalate intake may pose an increased risk of calcium oxalate stone formation.",
keywords = "calcium, diet, kidney calculi, oxalates",
author = "Matsumoto, {Edward D.} and Heller, {Howard J.} and Huet, {Beverley A} and Brinkley, {Linda J.} and Pak, {Charles Y} and Pearle, {Margaret S}",
year = "2006",
month = "7",
doi = "10.1016/S0022-5347(06)00565-9",
language = "English (US)",
volume = "176",
pages = "132--136",
journal = "Journal of Urology",
issn = "0022-5347",
publisher = "Elsevier Inc.",
number = "1",

}

TY - JOUR

T1 - Effect of High and Low Calcium Diets on Stone Forming Risk During Liberal Oxalate Intake

AU - Matsumoto, Edward D.

AU - Heller, Howard J.

AU - Huet, Beverley A

AU - Brinkley, Linda J.

AU - Pak, Charles Y

AU - Pearle, Margaret S

PY - 2006/7

Y1 - 2006/7

N2 - Purpose: Recent studies suggest that a high calcium diet protects against calcium oxalate stone formation. We compared the effect of high and low calcium diets on urinary saturation of calcium oxalate during liberal oxalate intake. Materials and Methods: A total of 10 healthy subjects (5 male, 5 female) participated in a 2-phase, randomized, crossover study comparing high (1,000 mg daily) and low (400 mg daily) calcium intake on a liberal oxalate diet (200 mg daily). During each phase subjects adhered to an instructed diet for 3 days followed by a controlled, metabolic diet for 4 days. Blood and 24-hour urine specimens collected on the last 2 days of each phase were analyzed for serum biochemistry studies and stone risk factors, respectively. Results: Urinary calcium was higher (mean ± SD 171 ± 64 vs 124 ± 49 mg daily, p = 0.002) and oxalate was lower (25 ± 4.8 vs 27 ± 4 mg daily, p = 0.02) on the high vs low calcium diet. Overall, the urinary relative saturation ratio of calcium oxalate was higher on the high compared with the low calcium diet (3.3 vs 2.5, p <0.0001) even after adjusting for confounding variables. Conclusions: In normal subjects urinary saturation of calcium oxalate was higher on a high calcium diet than a low calcium diet during liberal oxalate intake because the decrease in urinary oxalate did not overcome the effect of increased calcium. A high calcium diet during liberal oxalate intake may pose an increased risk of calcium oxalate stone formation.

AB - Purpose: Recent studies suggest that a high calcium diet protects against calcium oxalate stone formation. We compared the effect of high and low calcium diets on urinary saturation of calcium oxalate during liberal oxalate intake. Materials and Methods: A total of 10 healthy subjects (5 male, 5 female) participated in a 2-phase, randomized, crossover study comparing high (1,000 mg daily) and low (400 mg daily) calcium intake on a liberal oxalate diet (200 mg daily). During each phase subjects adhered to an instructed diet for 3 days followed by a controlled, metabolic diet for 4 days. Blood and 24-hour urine specimens collected on the last 2 days of each phase were analyzed for serum biochemistry studies and stone risk factors, respectively. Results: Urinary calcium was higher (mean ± SD 171 ± 64 vs 124 ± 49 mg daily, p = 0.002) and oxalate was lower (25 ± 4.8 vs 27 ± 4 mg daily, p = 0.02) on the high vs low calcium diet. Overall, the urinary relative saturation ratio of calcium oxalate was higher on the high compared with the low calcium diet (3.3 vs 2.5, p <0.0001) even after adjusting for confounding variables. Conclusions: In normal subjects urinary saturation of calcium oxalate was higher on a high calcium diet than a low calcium diet during liberal oxalate intake because the decrease in urinary oxalate did not overcome the effect of increased calcium. A high calcium diet during liberal oxalate intake may pose an increased risk of calcium oxalate stone formation.

KW - calcium

KW - diet

KW - kidney calculi

KW - oxalates

UR - http://www.scopus.com/inward/record.url?scp=33744504922&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33744504922&partnerID=8YFLogxK

U2 - 10.1016/S0022-5347(06)00565-9

DO - 10.1016/S0022-5347(06)00565-9

M3 - Article

VL - 176

SP - 132

EP - 136

JO - Journal of Urology

JF - Journal of Urology

SN - 0022-5347

IS - 1

ER -