Abstract
Background: The Dietary Approaches to Stop Hypertension (DASH) diet is recommended to manage blood pressure. TheDASH diet is low in saturated fat, but it is not clear whether saturated fat should be preferentially replaced with carbohydrate or unsaturated fat, especially cis-monounsaturated fat. Objective:Ameta-analysis of intervention studies comparing highcarbohydrate and high-cis-monounsaturated fat diets was conducted to increase understanding of the effect of carbohydrate and cismonounsaturated fat on blood pressure. Design: For study diets to be included in the analysis, they had to be isoenergetic, and the subjects' body weight had to remain stable. Ten studies (6 randomized crossover, 1 randomized parallel, and 3 nonrandomized) met the inclusion criteria. Results: According to the random-effects model, which incorporates between-study variation to estimate the overall effect, diets rich in carbohydrate resulted in significantly higher systolic blood pressure [x - difference: 2.6 (95% CI: 0.4, 4.7) mm Hg; P = 0.02] and diastolic blood pressure [1.8 (0.01, 3.6) mm Hg; P = 0.05] than did diets rich in cis-monounsaturated fat. When the meta-analysis was limited to randomized crossover studies, both systolic [1.3 (-0.3, 2.9) mm Hg; P = 0.11] and diastolic [0.9 (-0.2, 2.1) mm Hg; P = 0.11] blood pressure were higher with a high-carbohydrate than with a high cis-monounsaturated fat diet, but the differences were not significant. Conclusions: Diets rich in carbohydrate may be associated with slightly higher blood pressure than diets rich in cis-monounsaturated fat. However, the magnitude of the difference may not justify making recommendations to alter the carbohydrate and cismonounsaturated fat content of the diet to manage blood pressure.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1251-1256 |
| Number of pages | 6 |
| Journal | American Journal of Clinical Nutrition |
| Volume | 85 |
| Issue number | 5 |
| State | Published - May 1 2007 |
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Keywords
- Blood pressure
- High-carbohydrate diet
- High-cis-monounsaturated fat diet
- High-cis-MUFA diet
- Hypertension
- Meta-analysis
ASJC Scopus subject areas
- Medicine (miscellaneous)
- Food Science
Cite this
Effect of high-carbohydrate or high-cis-monounsaturated fat diets on blood pressure : A meta-analysis of intervention trials. / Shah, Meena; Adams-Huet, Beverley; Garg, Abhimanyu.
In: American Journal of Clinical Nutrition, Vol. 85, No. 5, 01.05.2007, p. 1251-1256.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Effect of high-carbohydrate or high-cis-monounsaturated fat diets on blood pressure
T2 - A meta-analysis of intervention trials
AU - Shah, Meena
AU - Adams-Huet, Beverley
AU - Garg, Abhimanyu
PY - 2007/5/1
Y1 - 2007/5/1
N2 - Background: The Dietary Approaches to Stop Hypertension (DASH) diet is recommended to manage blood pressure. TheDASH diet is low in saturated fat, but it is not clear whether saturated fat should be preferentially replaced with carbohydrate or unsaturated fat, especially cis-monounsaturated fat. Objective:Ameta-analysis of intervention studies comparing highcarbohydrate and high-cis-monounsaturated fat diets was conducted to increase understanding of the effect of carbohydrate and cismonounsaturated fat on blood pressure. Design: For study diets to be included in the analysis, they had to be isoenergetic, and the subjects' body weight had to remain stable. Ten studies (6 randomized crossover, 1 randomized parallel, and 3 nonrandomized) met the inclusion criteria. Results: According to the random-effects model, which incorporates between-study variation to estimate the overall effect, diets rich in carbohydrate resulted in significantly higher systolic blood pressure [x - difference: 2.6 (95% CI: 0.4, 4.7) mm Hg; P = 0.02] and diastolic blood pressure [1.8 (0.01, 3.6) mm Hg; P = 0.05] than did diets rich in cis-monounsaturated fat. When the meta-analysis was limited to randomized crossover studies, both systolic [1.3 (-0.3, 2.9) mm Hg; P = 0.11] and diastolic [0.9 (-0.2, 2.1) mm Hg; P = 0.11] blood pressure were higher with a high-carbohydrate than with a high cis-monounsaturated fat diet, but the differences were not significant. Conclusions: Diets rich in carbohydrate may be associated with slightly higher blood pressure than diets rich in cis-monounsaturated fat. However, the magnitude of the difference may not justify making recommendations to alter the carbohydrate and cismonounsaturated fat content of the diet to manage blood pressure.
AB - Background: The Dietary Approaches to Stop Hypertension (DASH) diet is recommended to manage blood pressure. TheDASH diet is low in saturated fat, but it is not clear whether saturated fat should be preferentially replaced with carbohydrate or unsaturated fat, especially cis-monounsaturated fat. Objective:Ameta-analysis of intervention studies comparing highcarbohydrate and high-cis-monounsaturated fat diets was conducted to increase understanding of the effect of carbohydrate and cismonounsaturated fat on blood pressure. Design: For study diets to be included in the analysis, they had to be isoenergetic, and the subjects' body weight had to remain stable. Ten studies (6 randomized crossover, 1 randomized parallel, and 3 nonrandomized) met the inclusion criteria. Results: According to the random-effects model, which incorporates between-study variation to estimate the overall effect, diets rich in carbohydrate resulted in significantly higher systolic blood pressure [x - difference: 2.6 (95% CI: 0.4, 4.7) mm Hg; P = 0.02] and diastolic blood pressure [1.8 (0.01, 3.6) mm Hg; P = 0.05] than did diets rich in cis-monounsaturated fat. When the meta-analysis was limited to randomized crossover studies, both systolic [1.3 (-0.3, 2.9) mm Hg; P = 0.11] and diastolic [0.9 (-0.2, 2.1) mm Hg; P = 0.11] blood pressure were higher with a high-carbohydrate than with a high cis-monounsaturated fat diet, but the differences were not significant. Conclusions: Diets rich in carbohydrate may be associated with slightly higher blood pressure than diets rich in cis-monounsaturated fat. However, the magnitude of the difference may not justify making recommendations to alter the carbohydrate and cismonounsaturated fat content of the diet to manage blood pressure.
KW - Blood pressure
KW - High-carbohydrate diet
KW - High-cis-monounsaturated fat diet
KW - High-cis-MUFA diet
KW - Hypertension
KW - Meta-analysis
UR - http://www.scopus.com/inward/record.url?scp=34248352634&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=34248352634&partnerID=8YFLogxK
M3 - Article
C2 - 17490960
AN - SCOPUS:34248352634
VL - 85
SP - 1251
EP - 1256
JO - American Journal of Clinical Nutrition
JF - American Journal of Clinical Nutrition
SN - 0002-9165
IS - 5
ER -