Effect of hydrosoluble vitamin E on erythrocyte membrane lipid composition in patients with advanced cirrhosis: An open-label pilot trial

Sophie Restellini, Mahnaz Alaei, Thomas Matthes, Omar Kherad, Antonio Moschetta, Laurent Spahr

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

Aim: Deficiency in vitamin E, a natural antioxidant, participates in abnormal erythrocyte membrane lipids, structural alterations and hemolysis in advanced cirrhosis. Poor absorption of fat-soluble vitamins limits full correction of deficiency with standard formulations in cirrhosis with cholestasis. The aim of the present study was to examine safety and effects of tocofersolan, a water-soluble derivative of vitamin E, on erythrocyte membrane lipids and anemia in patients with biopsy-proven advanced cirrhosis, vitamin E deficiency and hemolysis. Methods: Twenty patients (age, 53±10 years; Child class B/C, 8/12), with low plasma vitamin E, chronic anemia and hemolysis, received oral tocofersolan 700mg/day for 4 weeks. Erythrocyte membrane lipid composition (cholesterol [Chol], phospholipids [Phosph]) was determined by enzymatic assays. Total and conjugated bilirubin, hemoglobin and vitamin E were measured. Results: Abdominal pain occurred in one patient. Five patients received blood transfusions due to severe anemia. After 4 weeks, both Chol and Phosph decreased, but changes were not significant. Both plasma vitamin E (P<0.05) and hemoglobin (P<0.05) increased, together with a decrease in total (P<0.05) and conjugated (P<0.05) bilirubin. Conclusion: In patients with advanced cirrhosis, low vitamin E plasma levels and chronic anemia with hemolysis, oral tocofersolan was overall well tolerated, but did not affect erythrocyte membrane lipid composition.

Original languageEnglish (US)
Pages (from-to)890-897
Number of pages8
JournalHepatology Research
Volume45
Issue number8
DOIs
StatePublished - Aug 1 2015

Keywords

  • Acanthocytosis
  • Anemia
  • Cirrhosis
  • Erythrocyte membrane
  • Hemolysis
  • Vitamin E

ASJC Scopus subject areas

  • Hepatology
  • Infectious Diseases

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