Effect of interleukin-1 receptor antagonist and soluble tumor necrosis factor receptor in animal models of infection

M. M. Paris, I. R. Friedland, S. Ehrett, S. M. Hickey, K. D. Olsen, E. Hansen, E. J M A Thonar, G. H. McCracken

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33 Scopus citations


Intracisternal or intraarticular inoculation of rabbit recombinant interleukin (IL)-β and rabbit tumor necrosis factor-α combined with IL-l receptor antagonist (IL-l RA) and soluble tumor necrosis factor receptor (sTNFR), respectively, produced significantly less inflammation in rabbits than after inoculation of these cytokines alone. In contrast, when Haemophilus influenzae type b (Rib) or Rib lipooligosaccharide (LOS) was given intraarticularly with IL-lRA, sTNFR, or the combination, there was no significant or consistent modulation of synovial inflammation and cartilage proteoglycan degradation. In the experimental meningitis model, IL-IRA and sTNFR did not significantly reduce the meningeal inflammatory response associated with intracisternal inoculation of Rib LOS. These data indicate that specific cytokine inhibitors (sTNFR and IL-lRA) may not be effective in modulating inflammation induced by a broad inflammatory stimulus such as gram-negative bacteria or their products and suggest caution in using them to treat these infectious conditions in humans.

Original languageEnglish (US)
Pages (from-to)161-169
Number of pages9
JournalJournal of Infectious Diseases
Issue number1
StatePublished - Jan 1995


ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases

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