Effect of interleukin-1 receptor antagonist and soluble tumor necrosis factor receptor in animal models of infection

M. M. Paris, I. R. Friedland, S. Ehrett, S. M. Hickey, K. D. Olsen, E. Hansen, E. J M A Thonar, G. H. McCracken

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Abstract

Intracisternal or intraarticular inoculation of rabbit recombinant interleukin (IL)-1β and rabbit tumor necrosis factor-α combined with IL-1 receptor antagonist (IL-1RA) and soluble tumor necrosis factor receptor (sTNFR), respectively, produced significantly less inflammation in rabbits than after inoculation of these cytokines alone. In contrast, when Haemophilus influenzae type b (Hib) or Hib lipooligosaccharide (LOS) was given intraarticularly with IL-1RA, sTNFR, or the combination, there was no significant or consistent modulation of synovial inflammation and cartilage proteoglycan degradation. In the experimental meningitis model, IL-1RA and sTNFR did not significantly reduce the meningeal inflammatory response associated with intra-cisternal inoculation of Hib LOS. These data indicate that specific cytokine inhibitors (sTNFR and IL-1RA) may not be effective in modulating inflammation induced by a broad inflammatory stimulus such as gram-negative bacteria or their products and suggest caution in using them to treat these infectious conditions in humans.

Original languageEnglish (US)
Pages (from-to)161-169
Number of pages9
JournalJournal of Infectious Diseases
Volume171
Issue number1
StatePublished - 1995

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Interleukin-1 Receptors
Tumor Necrosis Factor Receptors
Haemophilus influenzae type b
Interleukins
Animal Models
Rabbits
Infection
Inflammation
Cytokines
Proteoglycans
Gram-Negative Bacteria
Interleukin-1
Meningitis
Cartilage
Theoretical Models
Tumor Necrosis Factor-alpha
lipid-linked oligosaccharides

ASJC Scopus subject areas

  • Immunology
  • Public Health, Environmental and Occupational Health

Cite this

Paris, M. M., Friedland, I. R., Ehrett, S., Hickey, S. M., Olsen, K. D., Hansen, E., ... McCracken, G. H. (1995). Effect of interleukin-1 receptor antagonist and soluble tumor necrosis factor receptor in animal models of infection. Journal of Infectious Diseases, 171(1), 161-169.

Effect of interleukin-1 receptor antagonist and soluble tumor necrosis factor receptor in animal models of infection. / Paris, M. M.; Friedland, I. R.; Ehrett, S.; Hickey, S. M.; Olsen, K. D.; Hansen, E.; Thonar, E. J M A; McCracken, G. H.

In: Journal of Infectious Diseases, Vol. 171, No. 1, 1995, p. 161-169.

Research output: Contribution to journalArticle

Paris, MM, Friedland, IR, Ehrett, S, Hickey, SM, Olsen, KD, Hansen, E, Thonar, EJMA & McCracken, GH 1995, 'Effect of interleukin-1 receptor antagonist and soluble tumor necrosis factor receptor in animal models of infection', Journal of Infectious Diseases, vol. 171, no. 1, pp. 161-169.
Paris, M. M. ; Friedland, I. R. ; Ehrett, S. ; Hickey, S. M. ; Olsen, K. D. ; Hansen, E. ; Thonar, E. J M A ; McCracken, G. H. / Effect of interleukin-1 receptor antagonist and soluble tumor necrosis factor receptor in animal models of infection. In: Journal of Infectious Diseases. 1995 ; Vol. 171, No. 1. pp. 161-169.
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