Effect of intravenously administered glucose on glucagon and insulin secretion during fat absorption

Richard Dobbs, Gerald R. Faloona, Roger H Unger

Research output: Contribution to journalArticle

8 Scopus citations

Abstract

The intravenous infusion of glucose was found to alter profoundly the response of insulin and glucagon to an intraduodenally administered fat meal in conscious dogs from that of dogs given only intravenous saline as a control. In the latter, insulin rose only 4 μU/ml and glucagon rose from 142 SEM ± 8 to a peak of 221 pg/ml SEM ± 50. When glucose was infused, raising plasma glucose above 170 mg 100 ml, the administration of fat was associated with a rise in mean insulin to 344 μU/ml, and glucagon remained suppressed by hyperglycemia to below baseline levels, despite the fat meal. The peak insulin response to a fat meal plus glucose infusion was more than three times the peak level observed when glucose was infused alone without a meal or with a nonabsorbable intraduodenal volume load in the form of mineral oil. This suggests that the absorption of fat elicits an entero-insular signal that is greatly potentiated by exogenous glucose. These glucose-induced changes in the hormonal response to a fat meal may mediate certain of the metabolic effects of carbohydrates.

Original languageEnglish (US)
Pages (from-to)69-75
Number of pages7
JournalMetabolism
Volume24
Issue number1
DOIs
StatePublished - Jan 1975

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

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