Effect of linoleic acid lipoxygenase derivatives on functional activity of neutrophils

V. M. Brovkovych, A. A. Moibenko, I. A. Butovich, S. D. Brovkovych, S. A. Ogyl

Research output: Contribution to journalArticle

Abstract

The effect of Hpoxygenase derivatives of 13-hydroperoxylinoleic add (13-HPODE) and 13- hydroxylinoleic add (13-HODE) on zymozan-induced chemiluminescence of rat neutrophils in vitro was evaluated. It was found that both derivatives inhibit functional activity of neutrophila. The extent of inhibition was changed by preincubation of neutrophils with arachidonic or linoleic acid. On the other hand, in experiments with dogs it was shown that the extent of such inhibition considerably increases after ischemia and reperfusion of myocardium. Thus we assume that the ratio of lipoxygenase derivatives of arachidonic and linoleic acid play the regulative role in functional activity of neutrophils. It was concluded, that lipoxygenase derivatives of linoleic acid inhibited the neutrophils functional activity.

Original languageEnglish (US)
JournalUkrain'skyi Biokhimichnyi Zhurnal
Volume68
Issue number3
StatePublished - 1996

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Lipoxygenase
Linoleic Acid
Neutrophils
Derivatives
Arachidonic Acid
Chemiluminescence
Luminescence
Reperfusion
Rats
Myocardium
Ischemia
Dogs
Experiments

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Biochemistry

Cite this

Effect of linoleic acid lipoxygenase derivatives on functional activity of neutrophils. / Brovkovych, V. M.; Moibenko, A. A.; Butovich, I. A.; Brovkovych, S. D.; Ogyl, S. A.

In: Ukrain'skyi Biokhimichnyi Zhurnal, Vol. 68, No. 3, 1996.

Research output: Contribution to journalArticle

Brovkovych, V. M. ; Moibenko, A. A. ; Butovich, I. A. ; Brovkovych, S. D. ; Ogyl, S. A. / Effect of linoleic acid lipoxygenase derivatives on functional activity of neutrophils. In: Ukrain'skyi Biokhimichnyi Zhurnal. 1996 ; Vol. 68, No. 3.
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AU - Ogyl, S. A.

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