Effect of linoleic acid lipoxygenase derivatives on functional activity of neutrophils

The effect of Hpoxygenase derivatives of 13-hydroperoxylinoleic add (13-HPODE) and 13- hydroxylinoleic add (13-HODE) on zymozan-induced chemiluminescence of rat neutrophils in vitro was evaluated. It was found that both derivatives inhibit functional activity of neutrophila. The extent of inhibition was changed by preincubation of neutrophils with arachidonic or linoleic acid. On the other hand, in experiments with dogs it was shown that the extent of such inhibition considerably increases after ischemia and reperfusion of myocardium. Thus we assume that the ratio of lipoxygenase derivatives of arachidonic and linoleic acid play the regulative role in functional activity of neutrophils. It was concluded, that lipoxygenase derivatives of linoleic acid inhibited the neutrophils functional activity.