Effect of low-dose propantheline on food-stimulated gastric acid secretion: comparison with an "optimal effective dose" and interaction with cimetidine.

M. Feldman, C. T. Richardson, W. L. Peterson, J. H. Walsh, J. S. Fordtran

Research output: Contribution to journalArticle

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Abstract

We evaluated the widely held notion that anticholinergic drugs must be used in near toxic doses to inhibit gastric acid secretion effectively. Nine patients with duodenal ulcer were studied after a low dose (15 mg) and after a near toxic dose (averaging 48 mg) of the anticholinergic, propantheline. Mean (+/- S.E.) inhibition of food-stimulated acid secretion was identical with the two doses of propantheline: 29 +/- 10 and 29 +/- 11 per cent, respectively. In addition, when 15 mg of propantheline was combined with the histamine H2-receptor antagonist, cimetidine, acid secretion was suppressed to a greater degree than with either drug alone. A low dose of propantheline is as effective as a near toxic dose in suppressing food-stimulated acid secretion and augments the inhibitory effect of cimetidine.

Original languageEnglish (US)
Pages (from-to)1427-1430
Number of pages4
JournalNew England Journal of Medicine
Volume297
Issue number26
StatePublished - Dec 29 1977

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Propantheline
Gastric Acid
Cimetidine
Poisons
Food
Cholinergic Antagonists
Acids
Histamine H2 Antagonists
Duodenal Ulcer
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Effect of low-dose propantheline on food-stimulated gastric acid secretion : comparison with an "optimal effective dose" and interaction with cimetidine. / Feldman, M.; Richardson, C. T.; Peterson, W. L.; Walsh, J. H.; Fordtran, J. S.

In: New England Journal of Medicine, Vol. 297, No. 26, 29.12.1977, p. 1427-1430.

Research output: Contribution to journalArticle

Feldman, M. ; Richardson, C. T. ; Peterson, W. L. ; Walsh, J. H. ; Fordtran, J. S. / Effect of low-dose propantheline on food-stimulated gastric acid secretion : comparison with an "optimal effective dose" and interaction with cimetidine. In: New England Journal of Medicine. 1977 ; Vol. 297, No. 26. pp. 1427-1430.
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