Effect of mild-to-moderate airflow limitation on exercise capacity

T. G. Babb, R. Viggiano, B. Hurley, B. Staats, J. R. Rodarte

Research output: Contribution to journalArticle

146 Citations (Scopus)

Abstract

To determine the effect of mild-to-moderate airflow limitation on exercise tolerance and end-expiratory lung volume (EELV), we studied 9 control subjects with normal pulmonary function [forced expired volume in 1 s (FFV1) 105% pred; % of forced vital capacity expired in 1 s (FEV1/FVC%) 81] and 12 patients with mild-to-moderate airflow limitation (FEV1 72% pred; FEV1/FVC% 58) during progressive cycle ergometry. Maximal exercise capacity was reduced in patients [69% of pred maximal O2 uptake (V̇O(2 max))] compared with controls (104% pred V̇O(2 max), P < 0.01); however, maximal expired minute ventilation-to-maximum voluntary ventilation ratio and maximal heart rate were not significantly different between controls and patients. Overall, there was a close relationship between V̇O(2 max) and FEV1 (r2 = 0.62). Resting EELV was similar between controls and patients [53% of total lung capacity (TLC)], but at maximal exercise the controls decreased EELV to 45% of TLC (P < 0.01 ), whereas the patients increased EELV to 58% of TLC (P < 0.05). Overall, EELV was significantly correlated to both V̇O(2 max) (r = -0.71, P < 0.001) and FEV1 (r = -0.68, P < 0.001).This relationsbip suggests a ventilatory influence on exercise capacity; however, the increased EELV and associated pleural pressures could influence cardiovascular function during exercise. We suggest that the increase in EELV should be considered a response reflective of the effect of airflow limitation on the ventilatory response to exercise.

Original languageEnglish (US)
Pages (from-to)223-230
Number of pages8
JournalJournal of Applied Physiology
Volume70
Issue number1
StatePublished - 1991

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Exercise
Lung
Total Lung Capacity
Maximal Voluntary Ventilation
Ergometry
Exercise Tolerance
Vital Capacity
Ventilation
Heart Rate
Pressure
prednylidene

ASJC Scopus subject areas

  • Endocrinology
  • Physiology
  • Orthopedics and Sports Medicine
  • Physical Therapy, Sports Therapy and Rehabilitation

Cite this

Babb, T. G., Viggiano, R., Hurley, B., Staats, B., & Rodarte, J. R. (1991). Effect of mild-to-moderate airflow limitation on exercise capacity. Journal of Applied Physiology, 70(1), 223-230.

Effect of mild-to-moderate airflow limitation on exercise capacity. / Babb, T. G.; Viggiano, R.; Hurley, B.; Staats, B.; Rodarte, J. R.

In: Journal of Applied Physiology, Vol. 70, No. 1, 1991, p. 223-230.

Research output: Contribution to journalArticle

Babb, TG, Viggiano, R, Hurley, B, Staats, B & Rodarte, JR 1991, 'Effect of mild-to-moderate airflow limitation on exercise capacity', Journal of Applied Physiology, vol. 70, no. 1, pp. 223-230.
Babb TG, Viggiano R, Hurley B, Staats B, Rodarte JR. Effect of mild-to-moderate airflow limitation on exercise capacity. Journal of Applied Physiology. 1991;70(1):223-230.
Babb, T. G. ; Viggiano, R. ; Hurley, B. ; Staats, B. ; Rodarte, J. R. / Effect of mild-to-moderate airflow limitation on exercise capacity. In: Journal of Applied Physiology. 1991 ; Vol. 70, No. 1. pp. 223-230.
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