Effect of multisite radio-frequency ablation on porcine renal function

David A. Duchene, D. Brooke Johnson, Lucas Jacomides, Kenneth Ogan, Arthur I Sagalowsky, Jeffrey A Cadeddu

Research output: Contribution to journalArticle

Abstract

Background and Purpose: The acute and long-term effects of radiofrequency ablation (RFA) on kidney function have not been well studied. The functional change when RFA is used in combination with renal ischemia is likewise unknown. Our goal was to determine the change in renal function caused by various volumes of RFA on a porcine kidney model and the effect cold ischemia had on the results. Materials and Methods: Twenty-two female pigs with solitary kidneys underwent various volumes of RFA both with and without cold ischemia. Animals were divided into control, 10%, 15%, and 20% ablation of the total kidney volume. Measurements of creatinine were obtained for 2 weeks. Results: In the nonischemic group, the mean acute (day 1-3) creatinine changes in control, 10%, 15%, and 20% ablations were 0.6, 2.4, 1.7, and 2.6 mg/dL, respectively. In the cold-ischemia group, the mean acute creatinine changes were 0.85, 2.33, 3.3, and 3.75 mg/dL, respectively. Regression line analysis demonstrated a positive linear relationship in both groups. Fourteen-day mean creatinine changes for the nonischemic group were similar to those in the control animals and did not show a correlation with ablation volume. The mean creatinine changes at 14 days in the cold-ischemia group showed a positive linear correlation with ablation volume. Conclusions: The volume of RFA correlates with an acute change in renal function in the porcine model for both nonischemic and cold-ischemia groups. This study may help predict the extent of acute renal dysfunction in patients undergoing RFA for large or multiple renal masses. These results also suggest renal function may recover after nonischemic RFA.

Original languageEnglish (US)
Pages (from-to)278-280
Number of pages3
JournalJournal of Endourology
Volume20
Issue number4
DOIs
StatePublished - Apr 2006

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Radio
Swine
Kidney
Cold Ischemia
Creatinine
Ischemia
Regression Analysis

ASJC Scopus subject areas

  • Urology

Cite this

Effect of multisite radio-frequency ablation on porcine renal function. / Duchene, David A.; Johnson, D. Brooke; Jacomides, Lucas; Ogan, Kenneth; Sagalowsky, Arthur I; Cadeddu, Jeffrey A.

In: Journal of Endourology, Vol. 20, No. 4, 04.2006, p. 278-280.

Research output: Contribution to journalArticle

Duchene, David A. ; Johnson, D. Brooke ; Jacomides, Lucas ; Ogan, Kenneth ; Sagalowsky, Arthur I ; Cadeddu, Jeffrey A. / Effect of multisite radio-frequency ablation on porcine renal function. In: Journal of Endourology. 2006 ; Vol. 20, No. 4. pp. 278-280.
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abstract = "Background and Purpose: The acute and long-term effects of radiofrequency ablation (RFA) on kidney function have not been well studied. The functional change when RFA is used in combination with renal ischemia is likewise unknown. Our goal was to determine the change in renal function caused by various volumes of RFA on a porcine kidney model and the effect cold ischemia had on the results. Materials and Methods: Twenty-two female pigs with solitary kidneys underwent various volumes of RFA both with and without cold ischemia. Animals were divided into control, 10{\%}, 15{\%}, and 20{\%} ablation of the total kidney volume. Measurements of creatinine were obtained for 2 weeks. Results: In the nonischemic group, the mean acute (day 1-3) creatinine changes in control, 10{\%}, 15{\%}, and 20{\%} ablations were 0.6, 2.4, 1.7, and 2.6 mg/dL, respectively. In the cold-ischemia group, the mean acute creatinine changes were 0.85, 2.33, 3.3, and 3.75 mg/dL, respectively. Regression line analysis demonstrated a positive linear relationship in both groups. Fourteen-day mean creatinine changes for the nonischemic group were similar to those in the control animals and did not show a correlation with ablation volume. The mean creatinine changes at 14 days in the cold-ischemia group showed a positive linear correlation with ablation volume. Conclusions: The volume of RFA correlates with an acute change in renal function in the porcine model for both nonischemic and cold-ischemia groups. This study may help predict the extent of acute renal dysfunction in patients undergoing RFA for large or multiple renal masses. These results also suggest renal function may recover after nonischemic RFA.",
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AU - Johnson, D. Brooke

AU - Jacomides, Lucas

AU - Ogan, Kenneth

AU - Sagalowsky, Arthur I

AU - Cadeddu, Jeffrey A

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N2 - Background and Purpose: The acute and long-term effects of radiofrequency ablation (RFA) on kidney function have not been well studied. The functional change when RFA is used in combination with renal ischemia is likewise unknown. Our goal was to determine the change in renal function caused by various volumes of RFA on a porcine kidney model and the effect cold ischemia had on the results. Materials and Methods: Twenty-two female pigs with solitary kidneys underwent various volumes of RFA both with and without cold ischemia. Animals were divided into control, 10%, 15%, and 20% ablation of the total kidney volume. Measurements of creatinine were obtained for 2 weeks. Results: In the nonischemic group, the mean acute (day 1-3) creatinine changes in control, 10%, 15%, and 20% ablations were 0.6, 2.4, 1.7, and 2.6 mg/dL, respectively. In the cold-ischemia group, the mean acute creatinine changes were 0.85, 2.33, 3.3, and 3.75 mg/dL, respectively. Regression line analysis demonstrated a positive linear relationship in both groups. Fourteen-day mean creatinine changes for the nonischemic group were similar to those in the control animals and did not show a correlation with ablation volume. The mean creatinine changes at 14 days in the cold-ischemia group showed a positive linear correlation with ablation volume. Conclusions: The volume of RFA correlates with an acute change in renal function in the porcine model for both nonischemic and cold-ischemia groups. This study may help predict the extent of acute renal dysfunction in patients undergoing RFA for large or multiple renal masses. These results also suggest renal function may recover after nonischemic RFA.

AB - Background and Purpose: The acute and long-term effects of radiofrequency ablation (RFA) on kidney function have not been well studied. The functional change when RFA is used in combination with renal ischemia is likewise unknown. Our goal was to determine the change in renal function caused by various volumes of RFA on a porcine kidney model and the effect cold ischemia had on the results. Materials and Methods: Twenty-two female pigs with solitary kidneys underwent various volumes of RFA both with and without cold ischemia. Animals were divided into control, 10%, 15%, and 20% ablation of the total kidney volume. Measurements of creatinine were obtained for 2 weeks. Results: In the nonischemic group, the mean acute (day 1-3) creatinine changes in control, 10%, 15%, and 20% ablations were 0.6, 2.4, 1.7, and 2.6 mg/dL, respectively. In the cold-ischemia group, the mean acute creatinine changes were 0.85, 2.33, 3.3, and 3.75 mg/dL, respectively. Regression line analysis demonstrated a positive linear relationship in both groups. Fourteen-day mean creatinine changes for the nonischemic group were similar to those in the control animals and did not show a correlation with ablation volume. The mean creatinine changes at 14 days in the cold-ischemia group showed a positive linear correlation with ablation volume. Conclusions: The volume of RFA correlates with an acute change in renal function in the porcine model for both nonischemic and cold-ischemia groups. This study may help predict the extent of acute renal dysfunction in patients undergoing RFA for large or multiple renal masses. These results also suggest renal function may recover after nonischemic RFA.

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