Effect of P-wave timing during supraventricular tachycardia on the hemodynamic and sympathetic neural response

Mohamed H. Hamdan, Jason D. Zagrodzky, Richard L. Page, Stephen L. Wasmund, Clifford J. Sheehan, Mathew M. Adamson, Jose A. Joglar, Michael L. Smith

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

Background - Previous studies have shown the importance of the timing of atrial and ventricular systole on the hemodynamic response during supraventricular tachycardia (SVT). However, the reflex changes in autonomic tone during SVT remain poorly understood. Methods and Results - Eleven patients with permanent dual-chamber pacemakers were enrolled in the study. Arterial blood pressure (BP), central venous pressure (CVP), and peripheral muscle sympathetic nerve activity (SNA) were recorded during DDD pacing at a rate of 175 bpm (cycle length 343 ms) with an atrioventricular (AV) interval of 30, 200 and 110 ms, simulating tachycardia with near-simultaneous atrial and ventricular systole, short-RP tachycardia (RP<PR), and long-RP tachycardia (RP>PR). Each pacing run was performed for 3 minutes separated by a 5-minute recovery period. All patients demonstrated an abrupt fall in BP, an increase in CVP, and an increase in SNA regardless of the AV interval. The decreases in SBP, DBP, and MAP and the increase in CVP were significantly less during long-RP tachycardia (AV interval 110 ms) than during the other 2 pacing modes (P<0.05), and the increase in SNA in 7 of the 11 patients was significantly greater during closely coupled atrial and ventricular systole than during long-RP tachycardia (P<0.05). Conclusions - These data suggest that the superior maintenance of hemodynamic stability during long-RP tachycardia is accompanied by reduced sympathoexcitation, which is primarily mediated by the arterial baroreceptors, with a modest cardiopulmonary vasodepressor effect.

Original languageEnglish (US)
Pages (from-to)96-101
Number of pages6
JournalCirculation
Volume103
Issue number1
StatePublished - Jan 9 2001

Fingerprint

Supraventricular Tachycardia
Tachycardia
Hemodynamics
Central Venous Pressure
Systole
Dichlorodiphenyldichloroethane
Pressoreceptors
Reflex
Arterial Pressure
Maintenance
Blood Pressure
Muscles

Keywords

  • Nervous system, autonomic
  • Pacing

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine

Cite this

Hamdan, M. H., Zagrodzky, J. D., Page, R. L., Wasmund, S. L., Sheehan, C. J., Adamson, M. M., ... Smith, M. L. (2001). Effect of P-wave timing during supraventricular tachycardia on the hemodynamic and sympathetic neural response. Circulation, 103(1), 96-101.

Effect of P-wave timing during supraventricular tachycardia on the hemodynamic and sympathetic neural response. / Hamdan, Mohamed H.; Zagrodzky, Jason D.; Page, Richard L.; Wasmund, Stephen L.; Sheehan, Clifford J.; Adamson, Mathew M.; Joglar, Jose A.; Smith, Michael L.

In: Circulation, Vol. 103, No. 1, 09.01.2001, p. 96-101.

Research output: Contribution to journalArticle

Hamdan, MH, Zagrodzky, JD, Page, RL, Wasmund, SL, Sheehan, CJ, Adamson, MM, Joglar, JA & Smith, ML 2001, 'Effect of P-wave timing during supraventricular tachycardia on the hemodynamic and sympathetic neural response', Circulation, vol. 103, no. 1, pp. 96-101.
Hamdan MH, Zagrodzky JD, Page RL, Wasmund SL, Sheehan CJ, Adamson MM et al. Effect of P-wave timing during supraventricular tachycardia on the hemodynamic and sympathetic neural response. Circulation. 2001 Jan 9;103(1):96-101.
Hamdan, Mohamed H. ; Zagrodzky, Jason D. ; Page, Richard L. ; Wasmund, Stephen L. ; Sheehan, Clifford J. ; Adamson, Mathew M. ; Joglar, Jose A. ; Smith, Michael L. / Effect of P-wave timing during supraventricular tachycardia on the hemodynamic and sympathetic neural response. In: Circulation. 2001 ; Vol. 103, No. 1. pp. 96-101.
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