TY - JOUR
T1 - Effect of parenteral amino acid supplementation in alcoholic hepatitis
AU - Diehl, Anna Mae
AU - Boitnott, John K.
AU - Herlong, H. Franklin
AU - Potter, James J.
AU - Duyn, Mary Ann Van
AU - Chandler, Elizabeth
AU - Mezey, Esteban
PY - 1985
Y1 - 1985
N2 - A controlled randomized study was performed in 15 patients with biopsy‐proven alcoholic hepatitis to determine the effect of the administration of a parenteral amino acid‐glucose solution for 1 month on nutritional, clinical, biochemical and histological parameters. All patients were allowed ad libitum consumption of a hospital diet. Five patients received the amino acid‐glucose solution, while 10 received the glucose solution without amino acids. There was more improvement in nitrogen balance in the treated group than the control group. However, amino acid therapy was no more beneficial than control therapy in improving creatinine‐height index, arm muscle area, arm fat area, and plasma levels of retinol binding proteins, prealbumin and pyridoxal‐5′‐phosphate. Clinical and biochemical markers of liver disease improved in both groups. This improvement in composite clinical index was more rapid in the treated than in the control group, but this early advantage was no longer apparent at the end of one month. Hepatocellular necrosis, inflammation and fat improved in the entire group. Amino acid treatment resulted in a greater resolution of fatty infiltration, but did not otherwise affect hepatic histology. Hepatocellular necrosis and inflammation in both the initial and final liver biopsies were highly correlated with nitrogen balance on admission. Initial clinical index correlated with the quantity of ethanol consumption prior to admission but not with liver injury on biopsy. However, by the end of the study, clinical index correlated with hepatocellular necrosis and inflammation. It is concluded that the clinical syndrome of alcoholic hepatitis is heavily influenced initially by metabolic consequences of alcohol consumption and that it is the resolution of this alcohol effect that is most influenced by parenteral amino acid supplementation.
AB - A controlled randomized study was performed in 15 patients with biopsy‐proven alcoholic hepatitis to determine the effect of the administration of a parenteral amino acid‐glucose solution for 1 month on nutritional, clinical, biochemical and histological parameters. All patients were allowed ad libitum consumption of a hospital diet. Five patients received the amino acid‐glucose solution, while 10 received the glucose solution without amino acids. There was more improvement in nitrogen balance in the treated group than the control group. However, amino acid therapy was no more beneficial than control therapy in improving creatinine‐height index, arm muscle area, arm fat area, and plasma levels of retinol binding proteins, prealbumin and pyridoxal‐5′‐phosphate. Clinical and biochemical markers of liver disease improved in both groups. This improvement in composite clinical index was more rapid in the treated than in the control group, but this early advantage was no longer apparent at the end of one month. Hepatocellular necrosis, inflammation and fat improved in the entire group. Amino acid treatment resulted in a greater resolution of fatty infiltration, but did not otherwise affect hepatic histology. Hepatocellular necrosis and inflammation in both the initial and final liver biopsies were highly correlated with nitrogen balance on admission. Initial clinical index correlated with the quantity of ethanol consumption prior to admission but not with liver injury on biopsy. However, by the end of the study, clinical index correlated with hepatocellular necrosis and inflammation. It is concluded that the clinical syndrome of alcoholic hepatitis is heavily influenced initially by metabolic consequences of alcohol consumption and that it is the resolution of this alcohol effect that is most influenced by parenteral amino acid supplementation.
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U2 - 10.1002/hep.1840050114
DO - 10.1002/hep.1840050114
M3 - Article
C2 - 3917968
AN - SCOPUS:0021924145
SN - 0270-9139
VL - 5
SP - 57
EP - 63
JO - Hepatology
JF - Hepatology
IS - 1
ER -