Effect of penicillin prophylaxis on nasopharyngeal colonization with Streptococcus pneumoniae in children with sickle cell anemia

David L. Anglin, Jane D. Siegel, David L. Pacini, Susan J. Smith, Greg Adams, George R. Buchanan

Research output: Contribution to journalArticle

37 Citations (Scopus)

Abstract

Polyavalent pneumococcal vaccine and oral penicillin prophylaxis are frequently used in patients with functional or anatomic asplenia to protect them from fulminant Streptococcus pneumoniae sepsis. We studied nasopharyngeal colonization with pneumococci in 34 patients with sickle cell anemia (aged 6 months to 5 years) receiving penicillin prophylaxis and in 63 age- and race-matched comparison patients. Patients with sickle cell anemia had fewer positive initial pneumococcal nasopharyngeal cultures than did the comparison group (14.5% vs 34.4%, P=0.03) and significantly lower carriage rates during the respiratory illness season of November to March (8.7% vs 40.5%, P=0.05). Penicillin prophylaxis did not result in emergence of penicillin-resistant pneumococci or in an increased carriage rate of Haemophilus influenzae type b. Our data suggest a mechanism of action for penicillin prophylaxis and provide some evidence for the relative safety of this regimen.

Original languageEnglish (US)
Pages (from-to)18-22
Number of pages5
JournalThe Journal of Pediatrics
Volume104
Issue number1
DOIs
StatePublished - 1984

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Sickle Cell Anemia
Streptococcus pneumoniae
Penicillins
Haemophilus influenzae type b
Pneumococcal Vaccines
Respiratory Rate
Sepsis
Safety

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Effect of penicillin prophylaxis on nasopharyngeal colonization with Streptococcus pneumoniae in children with sickle cell anemia. / Anglin, David L.; Siegel, Jane D.; Pacini, David L.; Smith, Susan J.; Adams, Greg; Buchanan, George R.

In: The Journal of Pediatrics, Vol. 104, No. 1, 1984, p. 18-22.

Research output: Contribution to journalArticle

Anglin, David L. ; Siegel, Jane D. ; Pacini, David L. ; Smith, Susan J. ; Adams, Greg ; Buchanan, George R. / Effect of penicillin prophylaxis on nasopharyngeal colonization with Streptococcus pneumoniae in children with sickle cell anemia. In: The Journal of Pediatrics. 1984 ; Vol. 104, No. 1. pp. 18-22.
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